(R)-(-)-Coniine

Base Information

• Chemical Name: (R)-(-)-Coniine
• CAS No.: 22160-08-3
• Molecular Formula: C7H15 N
• Molecular Weight: 113.2
• Hs Code.: 2933399090
• Mol file: 22160-08-3.mol

Synonyms:Piperidine,2-ethyl-, (R)-; Piperidine, 2-ethyl-, (R)-(-)- (8CI); (2R)-2-Ethylpiperidine;(R)-2-Ethylpiperidine

Chemical Property of (R)-(-)-Coniine

Chemical Property:

• PSA: 12.03000
• LogP: 1.86730
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-ETHYL-PIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-(-)-Coniine

There total 6 articles about (R)-(-)-Coniine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

C15H20O2 + 2-ethylpiperidine (1484-80-6,78738-37-1) → (R)-1-(3-mesitylpropanoyl)-2-ethyl piperidine (1346681-78-4) + (S)-1-(3-mesitylpropanoyl)-2-ethyl piperidine (1346681-76-2) + (-)-R-2-ethylpiperidine (22160-08-3)

Guidance literature:

With 2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; potassium carbonate; In Isopropyl acetate; at 23 ℃; for 24h; Resolution of racemate;

DOI:10.1039/c2cc34907h

Reference yield:

(R)-(1)-mandelic acid salt of (+)-2-ethyl-piperidine → (+)-2-ethyl-piperidine (1484-80-6,22160-08-3,34272-40-7,78738-37-1)

Guidance literature:

With potassium hydroxide; In water; pH=14;

Reference yield:

2-ethylpiperidine (1484-80-6,78738-37-1) → (+)-2-ethyl-piperidine (1484-80-6,22160-08-3,34272-40-7,78738-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; diethyl ether / 24 h / 0 °C / Resolution of racemate

2: potassium hydroxide / water / pH 14

With potassium hydroxide; In methanol; diethyl ether; water;

upstream raw materials:

2-ethylpiperidine

(S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-methoxy-2-phenylacetate

Downstream raw materials:

(R)-1-(2-ethylpiperidin-1-yl)-3-phenylpropan-1-one

(-)-R-trans-N-[β-(2-Methyl-6-phenyl-imidazo[2,1-b]-1,3,4-thiadiazol-5-yl)-propenoyl]-2-ethyl-piperidine

(2R,2'R)-2-(2-Ethylpiperidino)-3-phenyl-propionsaeure-methylester