Phenol, 3-chloro-2,4-difluoro-

Base Information

• Chemical Name: Phenol, 3-chloro-2,4-difluoro-
• CAS No.: 2268-00-0
• Molecular Formula: C6H3 Cl F2 O
• Molecular Weight: 164.54
• Hs Code.: 2908190090
• Mol file: 2268-00-0.mol

Synonyms:Phenol, 3-chloro-2,4-difluoro-

Chemical Property of Phenol, 3-chloro-2,4-difluoro-

Chemical Property:

• Boiling Point: 203℃
• Flash Point: 77℃
• PSA: 20.23000
• Density: 1.520
• LogP: 2.32380

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-2,4-difluorophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Chloro-2,4-difluorophenol is used in preparation of heteroaryl carboxamides as ubiquitin-specific protease inhibitors.

Technology Process of Phenol, 3-chloro-2,4-difluoro-

There total 1 articles about Phenol, 3-chloro-2,4-difluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-difluoro-3-chloro-aniline (2613-34-5) → 3-chloro-2,4-difluorophenol (2268-00-0)

Guidance literature:

With sulfuric acid; sodium nitrite; Erhitzen des Reaktionsgemisches mit Kupfer(II)-sulfat und wss. Schwefelsaeure auf 160grad;

DOI:10.1021/ja01510a021

Reference yield:

3-chloro-2,4-difluorophenol (2268-00-0) + trifluoroacetic acid (76-05-1) → 4-chloro-3,5-difluoro-2-hydroxybenzaldehyde

Guidance literature:

3-chloro-2,4-difluorophenol; trifluoroacetic acid; With hexamethylenetetramine; at 100 ℃; for 3h;

With sulfuric acid; In water; at 0 - 20 ℃; for 2h;

Reference yield:

3-chloro-2,4-difluorophenol (2268-00-0) + chloroacetic acid (79-11-8) → (3-chloro-2,4-difluoro-phenoxy)-acetic acid (1979-23-3)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01510a021

upstream raw materials:

2,4-difluoro-3-chloro-aniline

Downstream raw materials:

(3-chloro-2,4-difluoro-phenoxy)-acetic acid