2-amino-9H-indeno[2,1-d]pyrimidin-4-yl 4-nitrobenzenesulfonate

Base Information

• Chemical Name: 2-amino-9H-indeno[2,1-d]pyrimidin-4-yl 4-nitrobenzenesulfonate
• CAS No.: 1126602-50-3
• Molecular Formula: C₁₇H₁₂N₄O₅S
• Molecular Weight: 384.372
• Mol file: 1126602-50-3.mol

Synonyms:2-amino-9H-indeno[2,1-d]pyrimidin-4-yl 4-nitrobenzenesulfonate

Chemical Property of 2-amino-9H-indeno[2,1-d]pyrimidin-4-yl 4-nitrobenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-9H-indeno[2,1-d]pyrimidin-4-yl 4-nitrobenzenesulfonate

There total 3 articles about 2-amino-9H-indeno[2,1-d]pyrimidin-4-yl 4-nitrobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2-amino-3H,4H,9H-indeno[2,1-d]pyrimidin-4-one (1126602-49-0) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → 2-amino-9H-indeno[2,1-d]pyrimidin-4-yl 4-nitrobenzenesulfonate (1126602-50-3)

Guidance literature:

With triethylamine; dmap; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

ethyl 2-[2-(2-ethoxy-2-oxoethyl)phenyl]acetate (17532-66-0) → 2-amino-9H-indeno[2,1-d]pyrimidin-4-yl 4-nitrobenzenesulfonate (1126602-50-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium / toluene / 4 h / Reflux

2: potassium tert-butylate / tert-butyl alcohol / 4 h / 150 °C / Microwave irradiation

3: dmap; triethylamine / dichloromethane / 4 h / 20 °C

With dmap; potassium tert-butylate; sodium; triethylamine; In dichloromethane; toluene; tert-butyl alcohol; 1: Dieckmann reaction;

DOI:10.1016/j.bmc.2012.05.068

Reference yield:

1,2-phenylenediacetonitrile (613-73-0) → 2-amino-9H-indeno[2,1-d]pyrimidin-4-yl 4-nitrobenzenesulfonate (1126602-50-3)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / 6 h / Reflux

2: sodium / toluene / 4 h / Reflux

3: potassium tert-butylate / tert-butyl alcohol / 4 h / 150 °C / Microwave irradiation

4: dmap; triethylamine / dichloromethane / 4 h / 20 °C

With dmap; sulfuric acid; potassium tert-butylate; sodium; triethylamine; In dichloromethane; toluene; tert-butyl alcohol; 2: Dieckmann reaction;

DOI:10.1016/j.bmc.2012.05.068

upstream raw materials:

2-amino-3H,4H,9H-indeno[2,1-d]pyrimidin-4-one

4-Nitrobenzenesulfonyl chloride

ethyl 2-[2-(2-ethoxy-2-oxoethyl)phenyl]acetate

1,2-phenylenediacetonitrile

Downstream raw materials:

N₄-(2-isopropylphenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine

N₄-(3-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine

N₄-(3-chloro-4-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine

N₄-(4-(trifluoromethyl)phenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine