Carbonic acid (2S,5R)-5-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester ethyl ester

Base Information

Chemical Name:Carbonic acid (2S,5R)-5-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester ethyl ester
CAS No.:120885-73-6
Molecular Formula:C₂₀H₂₃N₃O₇
Molecular Weight:417.419
Hs Code.:

Synonyms:Carbonic acid (2S,5R)-5-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester ethyl ester

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Chemical Property of Carbonic acid (2S,5R)-5-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester ethyl ester

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Technology Process of Carbonic acid (2S,5R)-5-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester ethyl ester

There total 3 articles about Carbonic acid (2S,5R)-5-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1609-47-8
diethyl dicarbonate

: 120885-64-5
[1-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-carbamic acid benzyl ester

: 120885-73-6
Carbonic acid (2S,5R)-5-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester ethyl ester

Guidance literature:: With dmap; In pyridine; for 2h; Ambient temperature;
DOI:10.3891/acta.chem.scand.50-0609

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 120885-73-6
Carbonic acid (2S,5R)-5-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / 4-dimethylaminopyridine / dimethylformamide; pyridine / 18 h / Ambient temperature

2: 94 percent / 4-dimethylaminopyridine / pyridine / 2 h / Ambient temperature

With dmap; In pyridine; N,N-dimethyl-formamide;
DOI:10.3891/acta.chem.scand.50-0609

Reference yield:

: 7481-89-2
2`,3`-dideoxycytidine

: 120885-73-6
Carbonic acid (2S,5R)-5-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / 4-dimethylaminopyridine / dimethylformamide; pyridine / 18 h / Ambient temperature

2: 94 percent / 4-dimethylaminopyridine / pyridine / 2 h / Ambient temperature

With dmap; In pyridine; N,N-dimethyl-formamide;
DOI:10.3891/acta.chem.scand.50-0609