2-[4-(1-Cyclobutyl piperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone hydrochloride

Base Information

Chemical Name:2-[4-(1-Cyclobutyl piperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone hydrochloride
CAS No.:1394808-21-9
Molecular Formula:C₂₁H₃₁N₃O₃*ClH
Molecular Weight:409.956
Hs Code.:

Synonyms:2-[4-(1-Cyclobutyl piperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone hydrochloride

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Chemical Property of 2-[4-(1-Cyclobutyl piperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone hydrochloride

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Technology Process of 2-[4-(1-Cyclobutyl piperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone hydrochloride

There total 5 articles about 2-[4-(1-Cyclobutyl piperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1394808-83-3
2-[4-(1-cyclobutylpiperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone

: 1394808-21-9
2-[4-(1-Cyclobutyl piperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; at 20 ℃; for 1h;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1394808-21-9
2-[4-(1-Cyclobutyl piperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 5 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 10 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / Reflux

5.1: hydrogenchloride / diethyl ether; methanol / 1 h / 20 °C

With hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; palladium 10% on activated carbon; In methanol; diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 916905-62-9
4-(1-cyclobutylpiperidin-4-yloxy)-1-nitrobenzene

: 1394808-21-9
2-[4-(1-Cyclobutyl piperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / Reflux

3: hydrogenchloride / diethyl ether; methanol / 1 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; palladium 10% on activated carbon; In methanol; diethyl ether; N,N-dimethyl-formamide;