2-[4-(1-cyclobutylpiperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone

Base Information

Chemical Name:2-[4-(1-cyclobutylpiperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone
CAS No.:1394808-83-3
Molecular Formula:C₂₁H₃₁N₃O₃
Molecular Weight:373.495
Hs Code.:

Synonyms:2-[4-(1-cyclobutylpiperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone

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Chemical Property of 2-[4-(1-cyclobutylpiperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone

Chemical Property:

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Technology Process of 2-[4-(1-cyclobutylpiperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone

There total 4 articles about 2-[4-(1-cyclobutylpiperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1440-61-5
N-chloroacetylmorpholine

: 862310-33-6
4[(1-cyclobutyl-4-piperidinyl)oxy]aniline

: 1394808-83-3
2-[4-(1-cyclobutylpiperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; Reflux;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1394808-83-3
2-[4-(1-cyclobutylpiperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 5 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 10 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / Reflux

With hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; palladium 10% on activated carbon; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 916905-62-9
4-(1-cyclobutylpiperidin-4-yloxy)-1-nitrobenzene

: 1394808-83-3
2-[4-(1-cyclobutylpiperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / Reflux

With hydrogen; potassium carbonate; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;