(±)-benzyl 2-(3-(benzyloxy)-3-oxopropyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (±)-benzyl 2-(3-(benzyloxy)-3-oxopropyl)pyrrolidine-1-carboxylate
• CAS No.: 1620757-44-9
• Molecular Formula: C₂₂H₂₅NO₄
• Molecular Weight: 367.445
• Mol file: 1620757-44-9.mol

Synonyms:(±)-benzyl 2-(3-(benzyloxy)-3-oxopropyl)pyrrolidine-1-carboxylate

Chemical Property of (±)-benzyl 2-(3-(benzyloxy)-3-oxopropyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of (±)-benzyl 2-(3-(benzyloxy)-3-oxopropyl)pyrrolidine-1-carboxylate

There total 3 articles about (±)-benzyl 2-(3-(benzyloxy)-3-oxopropyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

benzylacrylate (2495-35-4,25036-21-9) + N-Benzyloxycarbonyl-L-proline (1148-11-4) → (±)-benzyl 2-(3-(benzyloxy)-3-oxopropyl)pyrrolidine-1-carboxylate (1620757-44-9)

Guidance literature:

With dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere; Photolysis; Sealed tube;

DOI:10.1021/ja505964r

Reference yield: 75.0%

→ (±)-benzyl 2-(3-(benzyloxy)-3-oxopropyl)pyrrolidine-1-carboxylate (1620757-44-9)

Guidance literature:

With dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; In N,N-dimethyl-formamide; for 36h; Inert atmosphere; Irradiation;

Reference yield: 65.0%

benzylacrylate (2495-35-4,25036-21-9) + 2,3-dihydro-pyrrole-1-carboxylic acid benzyl ester (68471-57-8) → (±)-benzyl 2-(3-(benzyloxy)-3-oxopropyl)pyrrolidine-1-carboxylate (1620757-44-9)

Guidance literature:

With disodium hydrogenphosphate; C₂₇H₅₀FeO₆; phenylsilane; In ethanol; at 60 ℃; chemoselective reaction;

DOI:10.1038/nature14006

upstream raw materials:

benzylacrylate

N-Benzyloxycarbonyl-L-proline

2,3-dihydro-pyrrole-1-carboxylic acid benzyl ester