(2S,3S)-O-acryloyl-N-(fluorenylmethyloxycarbonyl)-3-hydroxyleucine benzyl ester

Base Information

Chemical Name:(2S,3S)-O-acryloyl-N-(fluorenylmethyloxycarbonyl)-3-hydroxyleucine benzyl ester
CAS No.:1647153-67-0
Molecular Formula:C₃₁H₃₁NO₆
Molecular Weight:513.59
Hs Code.:

Synonyms:(2S,3S)-O-acryloyl-N-(fluorenylmethyloxycarbonyl)-3-hydroxyleucine benzyl ester

Suppliers and Price of (2S,3S)-O-acryloyl-N-(fluorenylmethyloxycarbonyl)-3-hydroxyleucine benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S)-O-acryloyl-N-(fluorenylmethyloxycarbonyl)-3-hydroxyleucine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S)-O-acryloyl-N-(fluorenylmethyloxycarbonyl)-3-hydroxyleucine benzyl ester

There total 6 articles about (2S,3S)-O-acryloyl-N-(fluorenylmethyloxycarbonyl)-3-hydroxyleucine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1647153-66-9
(2S,3S)-O-acryloyl-N-(fluorenylmethyloxycarbonyl)-3-hydroxyleucine

: 100-39-0
benzyl bromide

: 1647153-67-0
(2S,3S)-O-acryloyl-N-(fluorenylmethyloxycarbonyl)-3-hydroxyleucine benzyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 17h; Inert atmosphere;
DOI:10.3762/bjoc.10.113

Reference yield:

: 1647153-64-7
(2R,3S)-3-O-acryloyl-1-O-(tert-butyldimethylsilyl)-2-(fluorenylmethyloxycarbonyl-amino)-4-methyl-pentane-1,3-diol

: 1647153-67-0
(2S,3S)-O-acryloyl-N-(fluorenylmethyloxycarbonyl)-3-hydroxyleucine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: acetyl chloride / methanol / 3 h / 0 °C / Inert atmosphere

2: sodium hydrogencarbonate; sodium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid / water; acetone / 4.22 h / 0 °C

3: caesium carbonate / N,N-dimethyl-formamide / 17 h / 20 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid; sodium hydrogencarbonate; caesium carbonate; acetyl chloride; sodium bromide; In methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.3762/bjoc.10.113

Reference yield:

: 1647153-65-8
(2R,3S)-3-O-acryloyl-2-(fluorenylmethyloxycarbonylamino)-4-methyl-pentane-1,3-diol

: 1647153-67-0
(2S,3S)-O-acryloyl-N-(fluorenylmethyloxycarbonyl)-3-hydroxyleucine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; sodium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid / water; acetone / 4.22 h / 0 °C

2: caesium carbonate / N,N-dimethyl-formamide / 17 h / 20 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid; sodium hydrogencarbonate; caesium carbonate; sodium bromide; In water; N,N-dimethyl-formamide; acetone;
DOI:10.3762/bjoc.10.113