(R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid

Base Information

Chemical Name:(R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid
CAS No.:1015076-82-0
Molecular Formula:C₂₃H₂₅BrO₄S
Molecular Weight:477.419
Hs Code.:

Synonyms:(R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid

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Chemical Property of (R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid

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Technology Process of (R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid

There total 5 articles about (R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

: 1021952-71-5
(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol

: 162515-68-6
1-(sulfanylmethyl)cyclopropaneacetic acid

: 1015076-82-0
(R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid

Guidance literature:: 1-(sulfanylmethyl)cyclopropaneacetic acid; With sodium t-butanolate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol; In N,N-dimethyl-formamide; at 20 ℃; for 48.5h;

With tartaric acid; In water; ethyl acetate; N,N-dimethyl-formamide; pH=7; Product distribution / selectivity;

Reference yield: 61.1%

: 1015076-81-9
(S)-methyl 2-(3-(3-bromophenyl)-3-methylsulfonyloxypropyl)benzoate

: 162515-68-6
1-(sulfanylmethyl)cyclopropaneacetic acid

: 1015076-82-0
(R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid

Guidance literature:: 1-(sulfanylmethyl)cyclopropaneacetic acid; With sodium methylate; In tetrahydrofuran; for 0.5h; Inert atmosphere;

(S)-methyl 2-(3-(3-bromophenyl)-3-methylsulfonyloxypropyl)benzoate; In tetrahydrofuran; at -15 - 10 ℃; for 6.5h; Inert atmosphere;

Reference yield: 61.0%

: 1045844-78-7
methyl 2-[3-(R)-(3-bromophenyl)-3-(1-methoxycarbonylmethyl-cyclopropylmethylsulfanyl)-propyl]-benzoate

: 1015076-82-0
(R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid

Guidance literature:: methyl 2-[3-(R)-(3-bromophenyl)-3-(1-methoxycarbonylmethyl-cyclopropylmethylsulfanyl)-propyl]-benzoate; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 15h;

With acetic acid; In n-heptane; ethyl acetate;