(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol

Base Information

• Chemical Name: (S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol
• CAS No.: 1021952-71-5
• Molecular Formula: C₁₈H₂₀BrClO
• Molecular Weight: 367.713
• Mol file: 1021952-71-5.mol

Synonyms:(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol

Chemical Property of (S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol

There total 1 articles about (S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.4%

methyl magnesium iodide (917-64-6) + (S)-methyl 2-(3-(3-bromophenyl)-3-chloropropyl)benzoate (1021952-70-4) → (S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol (1021952-71-5)

Guidance literature:

methyl magnesium iodide; (S)-methyl 2-(3-(3-bromophenyl)-3-chloropropyl)benzoate; In diethyl ether; toluene; at 10 - 20 ℃; for 3.5h;

With water; ammonium chloride; In diethyl ether; toluene;

Reference yield: 87.5%

(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol (1021952-71-5) + 1-(sulfanylmethyl)cyclopropaneacetic acid (162515-68-6) → (R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid (1015076-82-0)

Guidance literature:

1-(sulfanylmethyl)cyclopropaneacetic acid; With sodium t-butanolate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol; In N,N-dimethyl-formamide; at 20 ℃; for 48.5h;

With tartaric acid; In water; ethyl acetate; N,N-dimethyl-formamide; pH=7; Product distribution / selectivity;

Reference yield: 67.8%

(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol (1021952-71-5) + 1-(sulfanylmethyl)cyclopropaneacetic acid (162515-68-6) → (1-{1-(R)-(3-bromophenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid (1015076-80-8)

Guidance literature:

1-(sulfanylmethyl)cyclopropaneacetic acid; With sodium t-butanolate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol; In N,N-dimethyl-formamide; at 20 ℃; for 48.5h;

With tartaric acid; In water; ethyl acetate; N,N-dimethyl-formamide; pH=7; Product distribution / selectivity;

upstream raw materials:

methyl magnesium iodide

(S)-methyl 2-(3-(3-bromophenyl)-3-chloropropyl)benzoate

Downstream raw materials:

(R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid

(1-{1-(R)-(3-bromophenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid