5-{3-[3-(3-hydroxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-6-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

Base Information

Chemical Name:5-{3-[3-(3-hydroxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-6-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile
CAS No.:1258852-35-5
Molecular Formula:C₂₅H₂₈N₄O₃
Molecular Weight:432.522
Hs Code.:

Synonyms:5-{3-[3-(3-hydroxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-6-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

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Chemical Property of 5-{3-[3-(3-hydroxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-6-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

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Technology Process of 5-{3-[3-(3-hydroxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-6-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

There total 8 articles about 5-{3-[3-(3-hydroxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-6-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1258855-43-4
2-[(1-methylethyl)oxy]-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-6-yl)-1,2,4-oxadiazol-5-yl]benzonitrile mono-trifluoroacetic acid salt

: 627-18-9
1-bromo-3-propanol

: 1258852-35-5
5-{3-[3-(3-hydroxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-6-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

Guidance literature:: With potassium carbonate; In acetone; at 90 ℃; for 0.333333h; Irradiation with microwave;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1258852-35-5
5-{3-[3-(3-hydroxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-6-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 4 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 3.5 h / 20 - 120 °C / Inert atmosphere

3: dichloromethane / 0 - 20 °C

4: potassium carbonate / acetone / 0.33 h / 90 °C / Irradiation with microwave

With oxalyl dichloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1072948-37-8
3-cyano-4-[(1-methylethyl)oxy]benzoyl chloride

: 1258852-35-5
5-{3-[3-(3-hydroxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-6-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 3.5 h / 20 - 120 °C / Inert atmosphere

2: dichloromethane / 0 - 20 °C

3: potassium carbonate / acetone / 0.33 h / 90 °C / Irradiation with microwave

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetone;