(S)-(E)-S-4-cyclohexylbut-3-en-2-yl 4-chlorophenyl(methyl)carbamothioate

Base Information

Chemical Name:(S)-(E)-S-4-cyclohexylbut-3-en-2-yl 4-chlorophenyl(methyl)carbamothioate
CAS No.:1613417-03-0
Molecular Formula:C₁₈H₂₄ClNOS
Molecular Weight:337.914
Hs Code.:

Synonyms:(S)-(E)-S-4-cyclohexylbut-3-en-2-yl 4-chlorophenyl(methyl)carbamothioate

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Chemical Property of (S)-(E)-S-4-cyclohexylbut-3-en-2-yl 4-chlorophenyl(methyl)carbamothioate

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Technology Process of (S)-(E)-S-4-cyclohexylbut-3-en-2-yl 4-chlorophenyl(methyl)carbamothioate

There total 5 articles about (S)-(E)-S-4-cyclohexylbut-3-en-2-yl 4-chlorophenyl(methyl)carbamothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 932-96-7
N-methyl(p-chloroaniline)

: 1415351-65-3
(E,S)-S-4-cyclohexylbut-3-en-2-yl 1H-imidazole-1-carbothioate

: 1613417-03-0
(S)-(E)-S-4-cyclohexylbut-3-en-2-yl 4-chlorophenyl(methyl)carbamothioate

Guidance literature:: With benzotriazol-1-ol; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere; Reflux;
DOI:10.1039/c4cc02596b

Reference yield:

: 79646-42-7,106499-63-2,120849-47-0,130930-52-8,18736-82-8,137764-95-5,79605-62-2
(E)-1-cyclohexyl-2-buten-1-ol

: 1613417-03-0
(S)-(E)-S-4-cyclohexylbut-3-en-2-yl 4-chlorophenyl(methyl)carbamothioate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / 1,2-dichloro-ethane / 26 h / 40 °C / Inert atmosphere

2: benzotriazol-1-ol / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere; Reflux

With dmap; benzotriazol-1-ol; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1039/c4cc02596b

Reference yield:

: 18736-82-8
1-cyclohexyl-but-2-en-1-ol

: 1613417-03-0
(S)-(E)-S-4-cyclohexylbut-3-en-2-yl 4-chlorophenyl(methyl)carbamothioate

Guidance literature:: Multi-step reaction with 4 steps

1: manganese(IV) oxide / chloroform / 132 h / 40 °C / Inert atmosphere

2: trans-RuCl₂((R)-2,2'-bis(di-3,5-xylylphosphino)-1,1'-binaphthyl)((R)-1,1-di(4-anisyl)-2-isopropyl-1,2-ethylenediamine); hydrogen; potassium carbonate / isopropyl alcohol / 168 h / 30 °C / 30003 Torr / Autoclave

3: dmap / 1,2-dichloro-ethane / 26 h / 40 °C / Inert atmosphere

4: benzotriazol-1-ol / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere; Reflux

With dmap; manganese(IV) oxide; trans-RuCl₂((R)-2,2'-bis(di-3,5-xylylphosphino)-1,1'-binaphthyl)((R)-1,1-di(4-anisyl)-2-isopropyl-1,2-ethylenediamine); hydrogen; potassium carbonate; benzotriazol-1-ol; In tetrahydrofuran; chloroform; 1,2-dichloro-ethane; isopropyl alcohol;
DOI:10.1039/c4cc02596b