(S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-cyclohexylpiperidine-3-yl)thiourea

Base Information

Chemical Name:(S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-cyclohexylpiperidine-3-yl)thiourea
CAS No.:1395408-52-2
Molecular Formula:C₂₀H₂₅F₆N₃S
Molecular Weight:453.495
Hs Code.:

Synonyms:(S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-cyclohexylpiperidine-3-yl)thiourea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-cyclohexylpiperidine-3-yl)thiourea

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Technology Process of (S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-cyclohexylpiperidine-3-yl)thiourea

There total 7 articles about (S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-cyclohexylpiperidine-3-yl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₁H₂₂N₂*(x)ClH

: 23165-29-9
3,5-bistrifluoromethylphenylisothiocyanate

: 1395408-52-2
(S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-cyclohexylpiperidine-3-yl)thiourea

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol302005f

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 1395408-52-2
(S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-cyclohexylpiperidine-3-yl)thiourea

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 16.5 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 10.25 h / 0 - 20 °C / Inert atmosphere

3: sodium tetrahydroborate; calcium chloride / ethanol / 4 h / Inert atmosphere

4: triethylamine / dichloromethane / 2 h / Inert atmosphere

5: 16 h / 20 °C / Inert atmosphere

6: methanol; hydrogenchloride / water / 16 h / 0 - 20 °C / Inert atmosphere

7: triethylamine / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; methanol; sodium tetrahydroborate; thionyl chloride; triethylamine; calcium chloride; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/ol302005f

Reference yield:

: 162955-48-8,397246-12-7
[(1S)-4-hydroxy-1-(hydroxymethyl)butyl]carbamic acid tert-butyl ester

: 1395408-52-2
(S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-cyclohexylpiperidine-3-yl)thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / Inert atmosphere

2: 16 h / 20 °C / Inert atmosphere

3: methanol; hydrogenchloride / water / 16 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; methanol; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol302005f