4-Methylphenyl beta-phenylpropionate

Base Information

• Chemical Name: 4-Methylphenyl beta-phenylpropionate
• CAS No.: 22020-95-7
• Molecular Formula: C16H16 O2
• Molecular Weight: 240.302
• Mol file: 22020-95-7.mol

Synonyms:Hydrocinnamicacid, p-tolyl ester (7CI,8CI)

Chemical Property of 4-Methylphenyl beta-phenylpropionate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methylphenyl beta-phenylpropionate

There total 7 articles about 4-Methylphenyl beta-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

p-cresol (106-44-5) + 3-phenylpropanoic dithioperoxyanhydride (119520-61-5) → 4-methylphenyl 3-phenylpropanoate (22020-95-7)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/acs.orglett.6b02818

Reference yield: 83.0%

4-tolyl iodide (624-31-7) + 3-Phenylpropionic acid (501-52-0) → 4-methylphenyl 3-phenylpropanoate (22020-95-7)

Guidance literature:

With palladium(II) trifluoroacetate; 4,7-dimethoxy-1,10-phenanthroline; silver trifluoroacetate; at 150 ℃; for 15h; Reagent/catalyst; chemoselective reaction; Catalytic behavior; Mechanism; Schlenk technique; Sealed tube;

DOI:10.1002/adsc.201901136

Reference yield: 82.0%

p-cresol (106-44-5) + hydrocinnamic acid chloride (645-45-4) → 4-methylphenyl 3-phenylpropanoate (22020-95-7)

Guidance literature:

With magnesium; In benzene; for 2h; Heating;

upstream raw materials:

p-cresol

hydrocinnamic acid chloride

3-phenylpropanoic dithioperoxyanhydride

4-formyl-2-methoxyphenyl 3-phenylpropanoate

Downstream raw materials:

1-(2-hydroxy-5-methylphenyl)-3-phenyl-1-propanone