3-t-butyldimethylsilyloxy-4-((4-ethylphenyl)methyl)-5-(trifluoromethyl)-1H-pyrazole

Base Information

• Chemical Name: 3-t-butyldimethylsilyloxy-4-((4-ethylphenyl)methyl)-5-(trifluoromethyl)-1H-pyrazole
• CAS No.: 421592-49-6
• Molecular Formula: C₁₉H₂₇F₃N₂OSi
• Molecular Weight: 384.517

Synonyms:3-t-butyldimethylsilyloxy-4-((4-ethylphenyl)methyl)-5-(trifluoromethyl)-1H-pyrazole

Chemical Property of 3-t-butyldimethylsilyloxy-4-((4-ethylphenyl)methyl)-5-(trifluoromethyl)-1H-pyrazole

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Technology Process of 3-t-butyldimethylsilyloxy-4-((4-ethylphenyl)methyl)-5-(trifluoromethyl)-1H-pyrazole

There total 2 articles about 3-t-butyldimethylsilyloxy-4-((4-ethylphenyl)methyl)-5-(trifluoromethyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,2-dihydro-4-[(4-ethylphenyl)-methyl]-5-(trifluoromethyl)-3H-pyrazole-3-one (152595-73-8) + tert-butyldimethylsilyl chloride (18162-48-6) → 3-t-butyldimethylsilyloxy-4-((4-ethylphenyl)methyl)-5-(trifluoromethyl)-1H-pyrazole (421592-49-6)

Guidance literature:

With 1H-imidazole; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 0.5 - 3h;

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) + 1,2-dihydro-4-(ethylphenyl)methyl-5-trifluoromethyl-3H-pyrazol-3-one (152595-73-8) → 3-t-butyldimethylsilyloxy-4-((4-ethylphenyl)methyl)-5-(trifluoromethyl)-1H-pyrazole (421592-49-6)

Guidance literature:

Reference yield: 83.0%

3-t-butyldimethylsilyloxy-4-((4-ethylphenyl)methyl)-5-(trifluoromethyl)-1H-pyrazole (421592-49-6) + benzyl alcohol (100-51-6,185532-71-2) → 4-[(4-ethylphenyl)methyl]-1-benzyl-5-trifluoromethyl-3-O-t-butyldimethylsilyl-1H-pyrazole (421592-51-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃; for 0.333333h;

upstream raw materials:

1,2-dihydro-4-[(4-ethylphenyl)-methyl]-5-(trifluoromethyl)-3H-pyrazole-3-one

tert-butyldimethylsilyl chloride

1,2-dihydro-4-(ethylphenyl)methyl-5-trifluoromethyl-3H-pyrazol-3-one

Downstream raw materials:

3-t-butyl dimethylsilyloxy-4-((4-ethylphenyl)methyl)-1-(1,3-difluoro-2-propyl)-5-(trifluoromethyl)pyrazole

1-cyclobutyl-4-[(4-ethylphenyl)methyl]-5-trifluoromethyl-3-O-t-butyldimethylsilyl-1H-pyrazole

4-[(4-ethylphenyl)methyl]-1-benzyl-5-trifluoromethyl-3-O-t-butyldimethylsilyl-1H-pyrazole

4-[(4-ethylphenyl)methyl]-1-phenyl-5-trifluoromethyl-3-O-t-butyldimethylsilyl-1H-pyrazole

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