N⁴-[6-Methoxy-5-(3-trifluoromethyl-phenoxy)-4-(3-trifluoromethyl-phenoxymethyl)-quinolin-8-yl]-pentane-1,4-diamine

Base Information

• Chemical Name: N⁴-[6-Methoxy-5-(3-trifluoromethyl-phenoxy)-4-(3-trifluoromethyl-phenoxymethyl)-quinolin-8-yl]-pentane-1,4-diamine
• CAS No.: 102781-12-4
• Molecular Formula: C₃₀H₂₉F₆N₃O₃
• Molecular Weight: 593.569

Synonyms:N⁴-[6-Methoxy-5-(3-trifluoromethyl-phenoxy)-4-(3-trifluoromethyl-phenoxymethyl)-quinolin-8-yl]-pentane-1,4-diamine

Chemical Property of N⁴-[6-Methoxy-5-(3-trifluoromethyl-phenoxy)-4-(3-trifluoromethyl-phenoxymethyl)-quinolin-8-yl]-pentane-1,4-diamine

Chemical Property:

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Technology Process of N⁴-[6-Methoxy-5-(3-trifluoromethyl-phenoxy)-4-(3-trifluoromethyl-phenoxymethyl)-quinolin-8-yl]-pentane-1,4-diamine

There total 4 articles about N⁴-[6-Methoxy-5-(3-trifluoromethyl-phenoxy)-4-(3-trifluoromethyl-phenoxymethyl)-quinolin-8-yl]-pentane-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-{4-[6-Methoxy-5-(3-trifluoromethyl-phenoxy)-4-(3-trifluoromethyl-phenoxymethyl)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione (102781-11-3) → N4-[6-Methoxy-5-(3-trifluoromethyl-phenoxy)-4-(3-trifluoromethyl-phenoxymethyl)-quinolin-8-yl]-pentane-1,4-diamine (102781-12-4)

Guidance literature:

With hydrazine; In tetrahydrofuran; ethanol; at 60 ℃; for 3h;

DOI:10.1021/jm00159a042

Reference yield:

3-Trifluoromethylphenol (98-17-9) → N4-[6-Methoxy-5-(3-trifluoromethyl-phenoxy)-4-(3-trifluoromethyl-phenoxymethyl)-quinolin-8-yl]-pentane-1,4-diamine (102781-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / KOH / CH₂Cl₂; dimethylformamide / 0.33 h / 60 °C

2: 95 percent / hydrazine / tetrahydrofuran; ethanol / 3 h / 60 °C

With potassium hydroxide; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00159a042

Reference yield:

4-(hydroxymethyl)-6-methoxy-8-<(4'-phthalimido-1'-methylbutyl)amino>-5-quinoline (102781-13-5) → N4-[6-Methoxy-5-(3-trifluoromethyl-phenoxy)-4-(3-trifluoromethyl-phenoxymethyl)-quinolin-8-yl]-pentane-1,4-diamine (102781-12-4)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂ / 1.) -15 deg C, 1 h, 2.) 0 deg C, 20 h, 3) 20 deg C, 0.5 h

2: 47 percent / KOH / CH₂Cl₂; dimethylformamide / 0.33 h / 60 °C

3: 95 percent / hydrazine / tetrahydrofuran; ethanol / 3 h / 60 °C

With potassium hydroxide; thionyl chloride; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00159a042

upstream raw materials:

2-{4-[6-Methoxy-5-(3-trifluoromethyl-phenoxy)-4-(3-trifluoromethyl-phenoxymethyl)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione

3-Trifluoromethylphenol

4-(hydroxymethyl)-6-methoxy-8-<(4'-phthalimido-1'-methylbutyl)amino>-5-quinoline

2-{4-[4-Chloromethyl-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione

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