(2,5-Dioxopyrrolidin-1-yl) 3-[(2,5-dioxopyrrolidin-1-yl)oxycarbonylamino]propanoate

Base Information

• Chemical Name: (2,5-Dioxopyrrolidin-1-yl) 3-[(2,5-dioxopyrrolidin-1-yl)oxycarbonylamino]propanoate
• CAS No.: 21994-89-8
• Molecular Formula: C₁₂H₁₃N₃O₈
• Molecular Weight: 327.251
• European Community (EC) Number: 893-316-0
• Mol file: 21994-89-8.mol

Synonyms:21994-89-8;Succinimidyloxycarbonyl-beta-alanine-hydroxysuccinimide ester;N-Succinimidoxycarbonyl-beta-alanine N-Succinimidyl Ester;(2,5-dioxopyrrolidin-1-yl) 3-[(2,5-dioxopyrrolidin-1-yl)oxycarbonylamino]propanoate;MFCD09952655;J-014400;succinimidyloxycarbonyl-b-alanine-hydroxysuccinimide ester;N-Succinimidoxycarbonyl- beta -alanine N-Succinimidyl Ester;N-[[N-[(Succinimidooxy)carbonyl]-beta-alanyl]oxy]succinimide

Chemical Property of (2,5-Dioxopyrrolidin-1-yl) 3-[(2,5-dioxopyrrolidin-1-yl)oxycarbonylamino]propanoate

Chemical Property:

• Melting Point: 163-164°C
• PSA: 157.85000
• LogP: -0.92620
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly)
• XLogP3: -2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 327.07026438
• Heavy Atom Count: 23
• Complexity: 555

Purity/Quality:

98.5% ^*data from raw suppliers

N-Succinimidoxycarbonyl-β-alanineN-SuccinimidylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)N(C1=O)OC(=O)CCNC(=O)ON2C(=O)CCC2=O
• Uses: b-Alanine, N-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]-, 2,5-dioxo-1-pyrrolidinyl ester can be used as a short, amino reactive homobifunctional crosslinking reagent. It is useful in polymer coupling to proteins, because it may lead to a better selectivity among all the amino groups present in a protein, thus yielding less heterogeneous PEG-protein conjugates mixture because only the most nucleophilic and solvent exposed amines can react. A short, amino reactive homobifunctional crosslinking reagent. Crosslinking distance 8.3. It is useful in polymer coupling to proteins, because it may lead to a better selectivity among all the amino groups present in a protein, thus yielding less heterogeneous PEG-protein conjugates mixture because only the most nucleophilic and solvent exposed amines can react.

Technology Process of (2,5-Dioxopyrrolidin-1-yl) 3-[(2,5-dioxopyrrolidin-1-yl)oxycarbonylamino]propanoate

There total 1 articles about (2,5-Dioxopyrrolidin-1-yl) 3-[(2,5-dioxopyrrolidin-1-yl)oxycarbonylamino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N-Succinimidoxycarbonyl-β-alanin-(N-hydroxysuccinimidester) (21994-89-8)

Guidance literature:

N-Hydroxy-succinimid, Dicyclohexylcarbodiimid, THF; Ausb.: 82percent;

DOI:10.1016/S0040-4020(01)96807-3

Reference yield:

N-Succinimidoxycarbonyl-β-alanin-(N-hydroxysuccinimidester) (21994-89-8) + aniline (62-53-3) → N-Phenylaminocarbonyl-β-alanin-phenylamid (21994-91-2)

Guidance literature:

In 1,4-dioxane; Heating;

DOI:10.1016/S0040-4020(01)96807-3

Reference yield:

N-Succinimidoxycarbonyl-β-alanin-(N-hydroxysuccinimidester) (21994-89-8) + benzylamine (100-46-9) → N-{2 (benzylaminocarbonyl)ethyl}-N'-benzyl urea (21994-90-1)

Guidance literature:

In 1,4-dioxane; Heating;

DOI:10.1016/S0040-4020(01)96807-3

Downstream raw materials:

N-Phenylaminocarbonyl-β-alanin-phenylamid

N-{2 (benzylaminocarbonyl)ethyl}-N'-benzyl urea