N-{2 (benzylaminocarbonyl)ethyl}-N'-benzyl urea

Base Information

• Chemical Name: N-{2 (benzylaminocarbonyl)ethyl}-N'-benzyl urea
• CAS No.: 21994-90-1
• Molecular Formula: C₁₈H₂₁N₃O₂
• Molecular Weight: 311.384
• Mol file: 21994-90-1.mol

Synonyms:N-{2 (benzylaminocarbonyl)ethyl}-N'-benzyl urea

Chemical Property of N-{2 (benzylaminocarbonyl)ethyl}-N'-benzyl urea

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-{2 (benzylaminocarbonyl)ethyl}-N'-benzyl urea

There total 4 articles about N-{2 (benzylaminocarbonyl)ethyl}-N'-benzyl urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-{[(4-methylphenyl)sulfonyl]oxy}pyrrolidine-2,5-dione (55048-39-0) + benzylamine (100-46-9) → N-{2 (benzylaminocarbonyl)ethyl}-N'-benzyl urea (21994-90-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2010.01.074

Reference yield: 52.0%

2,5-dioxopyrrolidin-1-yl 2,4,6-trimethylbenzenesulfonate (420131-99-3) + benzylamine (100-46-9) → N-{2 (benzylaminocarbonyl)ethyl}-N'-benzyl urea (21994-90-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2010.01.074

Reference yield:

N-Succinimidoxycarbonyl-β-alanin-(N-hydroxysuccinimidester) (21994-89-8) + benzylamine (100-46-9) → N-{2 (benzylaminocarbonyl)ethyl}-N'-benzyl urea (21994-90-1)

Guidance literature:

In 1,4-dioxane; Heating;

DOI:10.1016/S0040-4020(01)96807-3

upstream raw materials:

N-Succinimidoxycarbonyl-β-alanin-ethylester

benzylamine

N-Succinimidoxycarbonyl-β-alanin-(N-hydroxysuccinimidester)

2,5-dioxopyrrolidin-1-yl 2,4,6-trimethylbenzenesulfonate