Technology Process of C12H9F3N2O
There total 5 articles about C12H9F3N2O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; water;
In
tetrahydrofuran; diethyl ether;
at 20 ℃;
Inert atmosphere;
DOI:10.1016/j.bmcl.2011.07.103
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 85 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / -78 - -60 °C
2.2: 1 h / -78 °C
3.1: copper(l) iodide; cesium fluoride / 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Microwave irradiation
4.1: tetrahydrofuran; diethyl ether / 10 - 20 °C / Inert atmosphere
5.1: hydrogenchloride; water / tetrahydrofuran; diethyl ether / 20 °C / Inert atmosphere
With
hydrogenchloride; copper(l) iodide; n-butyllithium; water; potassium carbonate; cesium fluoride; L-proline;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.07.103
- Guidance literature:
-
Multi-step reaction with 3 steps
1: copper(l) iodide; cesium fluoride / 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Microwave irradiation
2: tetrahydrofuran; diethyl ether / 10 - 20 °C / Inert atmosphere
3: hydrogenchloride; water / tetrahydrofuran; diethyl ether / 20 °C / Inert atmosphere
With
hydrogenchloride; copper(l) iodide; water; cesium fluoride;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.07.103
