cis-1-azido-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Base Information

Chemical Name:cis-1-azido-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane
CAS No.:267405-12-9
Molecular Formula:C₂₁H₂₄N₄O₂
Molecular Weight:364.447
Hs Code.:

Synonyms:cis-1-azido-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

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Chemical Property of cis-1-azido-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

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Technology Process of cis-1-azido-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

There total 10 articles about cis-1-azido-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 267404-26-2
trans-1-(Methylsulfonyloxy)-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azapropyl)cyclohexane

: 267405-12-9
cis-1-azido-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00014-3

Reference yield:

: 25115-74-6
4-cyano-4-phenylcyclohexanone

: 267405-12-9
cis-1-azido-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / NaBH₄ / tetrahydrofuran / -78 °C

2: LiAlH₄ / tetrahydrofuran / Heating

3: 70 percent / Et₃N

4: 72 percent / PPh₃; DEAD

5: MeOH; NaOMe / tetrahydrofuran / 20 °C

6: HCl

7: 99 percent / Et₃N / 20 °C

8: Et₃N / CH₂Cl₂

9: NaN₃ / dimethylformamide

With hydrogenchloride; methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; sodium methylate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 4: Mitsunobu reaction;
DOI:10.1016/S0960-894X(03)00014-3

Reference yield:

: 21615-34-9
2-Methoxybenzoyl chloride

: 267405-12-9
cis-1-azido-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / Et₃N / 20 °C

2: Et₃N / CH₂Cl₂

3: NaN₃ / dimethylformamide

With sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00014-3