trans-1-(Methylsulfonyloxy)-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azapropyl)cyclohexane

Base Information

• Chemical Name: trans-1-(Methylsulfonyloxy)-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azapropyl)cyclohexane
• CAS No.: 267404-26-2
• Molecular Formula: C₂₂H₂₇NO₅S
• Molecular Weight: 417.526

Synonyms:trans-1-(Methylsulfonyloxy)-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azapropyl)cyclohexane

Chemical Property of trans-1-(Methylsulfonyloxy)-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azapropyl)cyclohexane

Chemical Property:

Purity/Quality:

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Technology Process of trans-1-(Methylsulfonyloxy)-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azapropyl)cyclohexane

There total 9 articles about trans-1-(Methylsulfonyloxy)-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azapropyl)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + trans-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane (267402-72-2) → trans-1-(Methylsulfonyloxy)-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azapropyl)cyclohexane (267404-26-2)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/S0960-894X(03)00014-3

Reference yield:

4-cyano-4-phenylcyclohexanone (25115-74-6) → trans-1-(Methylsulfonyloxy)-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azapropyl)cyclohexane (267404-26-2)

Guidance literature:

Multi-step reaction with 8 steps

1: 100 percent / NaBH₄ / tetrahydrofuran / -78 °C

2: LiAlH₄ / tetrahydrofuran / Heating

3: 70 percent / Et₃N

4: 72 percent / PPh₃; DEAD

5: MeOH; NaOMe / tetrahydrofuran / 20 °C

6: HCl

7: 99 percent / Et₃N / 20 °C

8: Et₃N / CH₂Cl₂

With hydrogenchloride; methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium methylate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 4: Mitsunobu reaction;

DOI:10.1016/S0960-894X(03)00014-3

Reference yield:

2-Methoxybenzoyl chloride (21615-34-9) → trans-1-(Methylsulfonyloxy)-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azapropyl)cyclohexane (267404-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / Et₃N / 20 °C

2: Et₃N / CH₂Cl₂

With triethylamine; In dichloromethane;

DOI:10.1016/S0960-894X(03)00014-3

upstream raw materials:

methanesulfonyl chloride

trans-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

4-cyano-4-phenylcyclohexanone

2-Methoxybenzoyl chloride

Downstream raw materials:

cis-1-amino-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

{4-[(2-methoxy-benzoylamino)-methyl]-4-phenyl-cyclohexyl}-carbamic acid 4-nitro-phenyl ester

4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)-cyclohex-1-ene

cis-1-azido-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

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