Boceprevir Metabolite M4-d9

Base Information

Chemical Name:Boceprevir Metabolite M4-d9
CAS No.:1373318-84-3
Molecular Formula:C₁₉H₃₃N₃O₄
Molecular Weight:376.417
Hs Code.:
Mol file:1373318-84-3.mol

Synonyms:C₁₉H₂₄⁽²⁾H₉N₃O₄

Suppliers and Price of Boceprevir Metabolite M4-d9

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
BoceprevirMetaboliteM4-d9
2.5mg
$ 2200.00

Total 3 raw suppliers

Chemical Property of Boceprevir Metabolite M4-d9

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

BoceprevirMetaboliteM4-d9 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses A labelled metabolite of the Hepatitis C virus NS3 serine protease inhibitor Boceprevir (B675500).

Technology Process of Boceprevir Metabolite M4-d9

There total 2 articles about Boceprevir Metabolite M4-d9 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1373318-83-2
C₂₀H₂₆⁽²⁾H₉N₃O₄

: 1373318-84-3
C₁₉H₂₄⁽²⁾H₉N₃O₄

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 7h; Inert atmosphere;
DOI:10.1002/jlcr.1960

Reference yield:

: (1R,2S,5S)-methyl 3-((S)-2-amino-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate hydrochloride

: 1373318-84-3
C₁₉H₂₄⁽²⁾H₉N₃O₄

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / dichloromethane / 0.5 h / 0 °C

1.2: 2.75 h / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 7 h / 20 °C / Inert atmosphere

With sodium hydrogencarbonate; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/jlcr.1960

Reference yield:

: 1036931-36-8,1996616-36-4,394735-23-0,1036931-35-7
3-amino-4-cyclobutyl-2-hydroxybutanamide hydrochloride

: 1373318-84-3
C₁₉H₂₄⁽²⁾H₉N₃O₄

: 1256751-11-7
[D₉]boceprevir

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 20 h / -20 - 20 °C / Inert atmosphere

2: dichloro-acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide; toluene / 20 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; dichloro-acetic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1002/jlcr.1960