1256751-11-7

Basic information

• Product Name: Boceprevir-d9
• Synonyms: Boceprevir-d9;(1R,2S,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[[1,1-di(methyl-d3)ethyl-2,2,2-d3]amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
• CAS NO: 1256751-11-7
• Molecular Formula: C₂₇H₄₅N₅O₅
• Molecular Weight: 519.6767
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals;Aromatics, Chiral Reagents, Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1256751-11-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO, Methanol
• CAS DataBase Reference: Boceprevir-d9(CAS DataBase Reference)
• NIST Chemistry Reference: Boceprevir-d9(1256751-11-7)
• EPA Substance Registry System: Boceprevir-d9(1256751-11-7)

Safety Data

• Hazardous Substances Data: 1256751-11-7(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

A labelled NS3 serine protease inhibitor of hepatitis C virus.

Upstream product

• 1373318-85-4 C₂₇H₃₈⁽²⁾H₉N₅O₅ 
• 1373318-83-2 C₂₀H₂₆⁽²⁾H₉N₃O₄ 
• 1036931-36-8 3-amino-4-cyclobutyl-2-hydroxybutanamide hydrochloride 
• 1373318-84-3 C₁₉H₂₄⁽²⁾H₉N₃O₄ 

Relevant articles and documents

Synthesis of [14C]boceprevir, [13C 3]boceprevir, and [D9]boceprevir, a hepatitis C virus protease inhibitor

Boceprevir is a hepatitis C virus (HCV) NS3 protease inhibitor for HCV treatment. [14C]Boceprevir (SCH 503034, trade name Victrelis) was synthesized from K14CN in 11 steps with an overall yield of 16.4%. [13C3]Boceprevir was synthesized in 16 steps with a 2.5% overall yield. The carbon-13 in the molecule was distributed along the peptide chain. [D9]Boceprevir was synthesized from [D9]-t- butylamine in four steps with an overall yield of 69%. Copyright 2012 John Wiley & Sons, Ltd. Boceprevir is an HCV NS3 protease inhibitor for HCV treatment. [14C]Boceprevir (SCH 503034, trade name Victrelis) was synthesized from K14CN in 11 steps with an overall yield of 16.4%. [13C3] Boceprevir was synthesized in 16 steps with a 2.5% overall yield. The carbon-13 in the molecule was distributed along the peptide chain. [D9]Boceprevir was synthesized from [D9]-t-butylamine in 4 steps with an overall yield of 69%.