8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-[(2R)-1-oxohexan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide

Base Information

• Chemical Name: 8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-[(2R)-1-oxohexan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide
• CAS No.: 1609165-88-9
• Molecular Formula: C₂₂H₂₃F₂N₃O₃
• Molecular Weight: 415.44
• Mol file: 1609165-88-9.mol

Synonyms:8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-[(2R)-1-oxohexan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide

Chemical Property of 8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-[(2R)-1-oxohexan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-[(2R)-1-oxohexan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide

There total 11 articles about 8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-[(2R)-1-oxohexan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-[(2,6-difluorobenzyl)oxy]-N-[(2R)-1-hydroxyhexan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide (1609163-76-9) → 8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-[(2R)-1-oxohexan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide (1609165-88-9)

Guidance literature:

With pyridine; Dess-Martin periodane; In dichloromethane; at -30 - 20 ℃; for 4h;

Reference yield:

8-hydroxy-N-[(2R)-1-hydroxyhexan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide (1609165-78-7) → 8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-[(2R)-1-oxohexan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide (1609165-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 0.67 h / 120 °C

2: Dess-Martin periodane; pyridine / dichloromethane / 4 h / -30 - 20 °C

With pyridine; potassium carbonate; Dess-Martin periodane; potassium iodide; In 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

8-(benzyloxy)-N-[(2R)-1-hydroxyhexan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide (1609163-91-8) → 8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-[(2R)-1-oxohexan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide (1609165-88-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C

2: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 0.67 h / 120 °C

3: Dess-Martin periodane; pyridine / dichloromethane / 4 h / -30 - 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; potassium carbonate; Dess-Martin periodane; potassium iodide; In 1-methyl-pyrrolidin-2-one; dichloromethane; ethyl acetate;

upstream raw materials:

8-(benzyloxy)-N-[(2R)-1-hydroxyhexan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

8-hydroxy-N-[(2R)-1-hydroxyhexan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

2,6-Difluorobenzyl bromide

2-amino-3-hydroxypyridine

Downstream raw materials:

8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-[(2R)-1-(morpholin-4-yl)hexan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide