benzoxazole-2-carboxylic acid (ethoxyphenylmethylene) hydrazide

Base Information

• Chemical Name: benzoxazole-2-carboxylic acid (ethoxyphenylmethylene) hydrazide
• CAS No.: 1445596-43-9
• Molecular Formula: C₁₇H₁₅N₃O₃
• Molecular Weight: 309.324
• Mol file: 1445596-43-9.mol

Synonyms:benzoxazole-2-carboxylic acid (ethoxyphenylmethylene) hydrazide

Chemical Property of benzoxazole-2-carboxylic acid (ethoxyphenylmethylene) hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzoxazole-2-carboxylic acid (ethoxyphenylmethylene) hydrazide

There total 3 articles about benzoxazole-2-carboxylic acid (ethoxyphenylmethylene) hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoxazole-2-carboxylic acid (21598-08-3) → benzoxazole-2-carboxylic acid (ethoxyphenylmethylene) hydrazide (1445596-43-9)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / ethanol / 4 h / 20 °C

2: triethylamine / 3 h / Reflux

3: hydrazine hydrate / ethanol / 8 h / Reflux

4: neat (no solvent) / 10 - 12 h / Reflux

With thionyl chloride; hydrazine hydrate; triethylamine; In ethanol;

DOI:10.1016/j.cclet.2013.04.005

Reference yield:

benzoxazole-2-carboxylic acid methyl ester (27383-86-4) → benzoxazole-2-carboxylic acid (ethoxyphenylmethylene) hydrazide (1445596-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 8 h / Reflux

2: neat (no solvent) / 10 - 12 h / Reflux

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.cclet.2013.04.005

Reference yield:

benzo[d]oxazole-2-carbonyl chloride (408538-63-6) → benzoxazole-2-carboxylic acid (ethoxyphenylmethylene) hydrazide (1445596-43-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / 3 h / Reflux

2: hydrazine hydrate / ethanol / 8 h / Reflux

3: neat (no solvent) / 10 - 12 h / Reflux

With hydrazine hydrate; triethylamine; In ethanol;

DOI:10.1016/j.cclet.2013.04.005

upstream raw materials:

benzoxazole-2-carboxylic acid methyl ester

benzoxazole-2-carboxylic acid

benzo[d]oxazole-2-carbonyl chloride

Downstream raw materials:

2-(5-phenyl-[1,3,4]oxadiazol-2-yl)benzoxazole