27383-86-4Relevant academic research and scientific papers
Visible-Light-Induced Aerobic Oxidative Csp3?H Functionalization of Glycine Derivatives for 2-Substituted Benzoxazoles
Zhu, Zhi-Qiang,Liu, Shan,Hu, Zhi-Yu,Xie, Zong-Bo,Tang, Juan,Le, Zhang-Gao
, p. 2568 - 2572 (2021)
We report a simple oxidative Csp3?H functionalization reaction of glycine derivatives by visible-light photoredox catalysis. A wide range of glycine derivatives readily undergo the oxidative cyclization to afford various 2-substituted benzoxazoles. Importantly, this photocatalytic intramolecular dehydrogenative coupling reaction allows for the C?H functionalization of glycine derivatives involving short peptides under mild conditions, which may have value in preparing peptide-derived pharmacologically active molecules. (Figure presented.).
Ag(I)-Catalyzed C-H Carboxylation of Thiophene Derivatives
Lee, Mijung,Hwang, Young Kyu,Kwak, Jaesung
, p. 3136 - 3144 (2021/09/30)
CO2utilization is an attractive aspect as it allows the direct conversion of CO2into valuable chemicals. In this regard, direct incorporation of CO2into the C-H bond of heteroaromatic compounds is important due to the ubiquitous structural motifs of the heteroaromatic carboxylic acids. Herein, we report the Ag-catalyzed C-H carboxylation of thiophene derivatives. This new catalytic system involving a phosphine ligand and lithiumtert-butoxide enables the direct carboxylation of thiophenes under mild reaction conditions. Experimental studies revealed that the use oftert-butyl alkoxide is critical for the exergonic formation of an arylsilver intermediate, and the results were further supported by density functional theory calculations.
2-substituted benzoxazole compound
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Paragraph 0012; 0020-0023, (2021/03/13)
The invention discloses a 2-substituted benzoxazole compound which is characterized in that the structural formula of the 2-substituted benzoxazole compound is shown as a formula (I), in the formula,R1 is a hydrogen atom, an electron donating group or an electron withdrawing group, R1 is connected with phenyl, and R2 is an alkoxy group or a substituted amino group. The synthesis method comprisesthe following steps: in the presence of a photosensitizer and a transition metal salt, irradiating an N-arylglycine derivative (I) at room temperature through visible light in an organic solvent, performing stirring and reacting for 12-16 hours until TLC (Thin Layer Chromatography) detection reaction is complete, concentrating the reaction solution, and carrying out column chromatography separation to obtain the product 2-substituted benzoxazole (II).
Copper-catalyzed oxidative cyclization of glycine derivatives toward 2-substituted benzoxazoles
Liu, Shan,Zhu, Zhi-Qiang,Hu, Zhi-Yu,Tang, Juan,Yuan, En
supporting information, p. 1616 - 1619 (2021/03/01)
A novel and straightforward intramolecular cyclization of glycine derivatives to 2-substituted benzoxazoles through copper-catalyzed oxidative C-H/O-H cross-coupling was described. A variety of glycine derivatives involving short peptides underwent cross-dehydrogenative-coupling readily to afford diverse 2-substituted benzoxazoles. The synthetic method has the advantages of simple operation, broad substrate scope and mild reaction conditions, thus providing an alternative effective approach for benzoxazole construction.
Discovery of heterocyclic carbohydrazide derivatives as novel selective fatty acid amide hydrolase inhibitors: design, synthesis and anti-neuroinflammatory evaluation
Hao, Qingjing,He, Mengting,Jiang, Kaixuan,Shang, Yanguo,Wang, Jinxin
supporting information, (2020/04/08)
Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat pain, inflammation, and other central nervous system disorders. Herein, a series of novel heterocyclic carbohydrazide derivatives were firstly designed by the classic scaffold-hopping strategy. Then, multi-steps synthesis and human FAAH enzyme inhibiting activity assays were conducted. Among them, compound 26 showed strong inhibition against human FAAH with IC50 of 2.8 μM. Corresponding docking studies revealed that the acyl hydrazide group of compound 26 well-occupied the acyl-chain binding pocket. It also exhibited high selectivity towards FAAH when comparing with CES2 and MAGL. Additionally, compound 26 effectively suppressed the LPS-induced neuroinflammation of microglial cells (BV2) via the reduction of interleukin-1β and tumor necrosis factor-α. Our results provided significative lead compounds for the further discovery of novel selective and safe FAAH inhibitors with potent anti-neuroinflammation activity.
On the design of new europium heteroaromatic carboxylates for OLED application
Koshelev, Daniil S.,Chikineva, Tatyana Yu,Kozhevnikova (Khudoleeva), Vladislava Yu,Medvedko, Alexey V.,Vashchenko, Andrey A.,Goloveshkin, Alexander S.,Tsymbarenko, Dmitry M.,Averin, Alexey A.,Meschkov, Anna,Schepers, Ute,Vatsadze, Sergey Z.,Utochnikova, Valentina V.
, (2019/06/18)
The approach to the directed synthesis of lanthanide aromatic carboxylates – precursors to the electroluminescent materials, - was proposed, namely the conjugation length increase and heteroatom introduction in the appropriate position in combination with
Binuclear molybdenum alkoxide as the versatile catalyst for the conversion of carbon dioxide
Chen, Jing-Huo,Deng, Cheng-Hua,Fang, Sheng,Ma, Jian-Gong,Cheng, Peng
, p. 989 - 996 (2018/03/13)
The triply bonded dimolybdenum compound, Mo2(OtBu)6 (1), was investigated as a homogeneous catalyst for the conversion of CO2. The compound 1 acted as a rare example of a versatile catalyst with an impressive ability to transform CO2 into various valuable products, including propiolic acids, cyclic carbonates, and benzo[d]thiazole- and benzo[d]oxazolecarboxylic acids, in high yields with short reaction times and excellent selectivity at ambient pressure and low temperatures (25-75 °C). This is the first report of the application of a metal-metal bond-containing species in the catalytic conversion of CO2.
Method of synthesizing heteroaromatic formic ether compound
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Paragraph 0021, (2017/08/19)
The invention discloses a method of synthesizing a heteroaromatic formic ether compound. By taking midazolium chloride salt of which the molecular formula is [(ArN=C(CH3)NCH2CH2NCH2C6H5)CH]Cl (wherein Ar is equal to 2,6-bi-CH(CH3)2-C6H3) as a catalyst, the heteroaromatic formic ether compound is synthesized through carboxylation reaction of a heteroaromatic compound and carbon dioxide at atmospheric pressure. The heteroaromatic formic ether compound is a first example that is catalyzed by imidazolium salt and prepared through the carboxylation reaction of the heteroaromatic compound and carbon dioxide. Compared with the prior art, the catalyst is green, the synthesis is easier, reaction conditions are mild, and the heteroaromatic formic ether compound has equivalent or better catalytic activity and functional group tolerance.
C-H carboxylation of heteroarenes with ambient CO2
Fenner, Sabine,Ackermann, Lutz
supporting information, p. 3804 - 3807 (2016/07/07)
The C-H carboxylation of heteroarenes was achieved under transition metal-free reaction conditions with naturally abundant CO2 as the C1 source at relatively low temperature. The C-H carboxylation was mediated by KOt-Bu at atmospheric pressure
METHOD FOR PROMOTING PLANT GROWTH
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Paragraph 1218; 1219, (2015/11/17)
The present invention provides a method for promoting plant growth, which comprises treating a plant with at least one compound represented by the following Formula (1) The compounds indicated by formula (1) are used to promote the growth of plants. A pla
