PHENYL-M-TOLYL-METHANOL

Base Information

• Chemical Name: PHENYL-M-TOLYL-METHANOL
• CAS No.: 21945-66-4
• Molecular Formula: C₁₄H₁₄O
• Molecular Weight: 198.265
• Mol file: 21945-66-4.mol

Synonyms:AURORA KA-7056;PHENYL-M-TOLYL-METHANOL

Chemical Property of PHENYL-M-TOLYL-METHANOL

Chemical Property:

• Vapor Pressure: 5.94E-05mmHg at 25°C
• Melting Point: 52 °C
• Refractive Index: 1.59
• Boiling Point: 332.1°C at 760 mmHg
• PKA: 13.82±0.20(Predicted)
• Flash Point: 143.7°C
• PSA: 20.23000
• Density: 1.081g/cm³
• LogP: 3.07670

Purity/Quality:

99% ^*data from raw suppliers

PHENYL-M-TOLYL-METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PHENYL-M-TOLYL-METHANOL

There total 27 articles about PHENYL-M-TOLYL-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzaldehyde (100-52-7) + m-tolylmagnesium bromide (28987-79-3) → 3-methylbenzhydrol (137474-24-9,137474-27-2,137474-29-4,21945-66-4)

Guidance literature:

In tetrahydrofuran; at 10 ℃;

DOI:10.1016/j.bmcl.2004.01.012

Reference yield: 95.0%

m-tolyl aldehyde (620-23-5) → 3-methylbenzhydrol (137474-24-9,137474-27-2,137474-29-4,21945-66-4)

Guidance literature:

phenylboronic acid; With trimethyl gallium; In toluene; at 20 ℃; for 2h; Inert atmosphere;

m-tolyl aldehyde; In toluene; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1055/s-0028-1087552

Reference yield: 92.0%

triphenylboroxine (3262-89-3) + m-tolyl aldehyde (620-23-5) → 3-methylbenzhydrol (137474-24-9,137474-27-2,137474-29-4,21945-66-4)

Guidance literature:

With sodium t-butanolate; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; In 1,2-dimethoxyethane; water; at 100 ℃; for 48h;

DOI:10.1016/j.tetlet.2007.04.025

upstream raw materials:

3-methyl benzophenone

benzaldehyde

m-tolylmagnesium bromide

1,2-diphenyl-1,2-di-m-tolyl-ethane-1,2-diol

Downstream raw materials:

3-methyl-benzhydryl chloride

(-)-(S)-(3-methylphenyl)(phenyl)methanol

water

1-Methyl-4-(phenyl-m-tolyl-methoxy)-piperidine

Refernces

• 1、 Lapa, Gennady B.,Lapa, Alla A.. "Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors". . p. 203 - 205. Retrieved 2019/04/25.
• 2、 Kobayashi, Shoji,Tamura, Tomoki,Yoshimoto, Saki,Kawakami, Takashi,Masuyama, Araki. "4-Methyltetrahydropyran (4-MeTHP): Application as an Organic Reaction Solvent". . p. 3921 - 3937. Retrieved 2019/11/11.