6-Benzyloxy-2,2-dimethylchroman-4-ol

Base Information

Chemical Name:6-Benzyloxy-2,2-dimethylchroman-4-ol
CAS No.:223749-51-7
Molecular Formula:C₁₈H₂₀O₃
Molecular Weight:284.355
Hs Code.:
DSSTox Substance ID:DTXSID401176234

Synonyms:SCHEMBL6937137;OFHFBVYXWZHZOU-UHFFFAOYSA-N;DTXSID401176234;AKOS015061167;6-benzyloxy-2,2-dimethylchroman-4-ol;3,4-Dihydro-2,2-dimethyl-6-(phenylmethoxy)-2H-1-benzopyran-4-ol;223749-51-7

Suppliers and Price of 6-Benzyloxy-2,2-dimethylchroman-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-Benzyloxy-2,2-dimethylchroman-4-ol

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:284.14124450
Heavy Atom Count:21
Complexity:335

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(CC(C2=C(O1)C=CC(=C2)OCC3=CC=CC=C3)O)C

Technology Process of 6-Benzyloxy-2,2-dimethylchroman-4-ol

There total 3 articles about 6-Benzyloxy-2,2-dimethylchroman-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171876-69-0
6-(benzyloxy)-2,2-dimethylchroman-4-one

: 223749-51-7
6-benzyloxy-2,2-dimethylchroman-4-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃;
DOI:10.1021/jm0109255

Reference yield:

: 31366-85-5
6-hydroxy-2,2-dimethyl-chroman-4-one

: 223749-51-7
6-benzyloxy-2,2-dimethylchroman-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 1 h / 20 °C

1.2: dimethylformamide / 20 °C

2.1: NaBH₄ / methanol / 20 °C

With sodium tetrahydroborate; sodium hydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0109255

Reference yield:

: 490-78-8
2,5-Dihydroxyacetophenone

: 223749-51-7
6-benzyloxy-2,2-dimethylchroman-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 82 percent / pyrrolidine / acetonitrile / 8 h / 45 °C

2.1: NaH / dimethylformamide / 1 h / 20 °C

2.2: dimethylformamide / 20 °C

3.1: NaBH₄ / methanol / 20 °C

With pyrrolidine; sodium tetrahydroborate; sodium hydride; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0109255