Technology Process of 5-{[2-(methylamino)ethyl]oxy}-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide
There total 8 articles about 5-{[2-(methylamino)ethyl]oxy}-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,1-dimethylethyl methyl[2-({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}oxy)ethyl]carbamate;
With
trifluoroacetic acid;
In
dichloromethane;
at 30 ℃;
for 2h;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
pH=7 - 8;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetone / 0.5 h / 20 °C
1.2: 7 h / Reflux
2.1: Reflux
3.1: potassium hydroxide; water / ethanol / Reflux
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 - 25 °C
5.1: sodium hydride / dimethyl sulfoxide / 0 - 20 °C
5.2: 18 h / 75 °C
6.1: trifluoroacetic acid / dichloromethane / 2 h / 30 °C
6.2: pH 7 - 8
With
water; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide;
In
ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetone / 0.5 h / 20 °C
1.2: 7 h / Reflux
1.3: Reflux
2.1: potassium hydroxide; water / ethanol / Reflux
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 - 25 °C
4.1: sodium hydride / dimethyl sulfoxide / 0 - 20 °C
4.2: 18 h / 75 °C
5.1: trifluoroacetic acid / dichloromethane / 2 h / 30 °C
5.2: pH 7 - 8
With
water; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide;
In
ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
![1,1-dimethylethyl methyl[2-({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}oxy)ethyl]carbamate](/Databaselist/images/loading.webp)
