4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenol

Base Information

Chemical Name:4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenol
CAS No.:1448000-73-4
Molecular Formula:C₃₂H₃₃BrO₆
Molecular Weight:593.514
Hs Code.:

Synonyms:4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenol

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Chemical Property of 4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenol

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Technology Process of 4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenol

There total 14 articles about 4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1448000-81-4
1-(benzyloxy)-4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)benzene

: 1448000-73-4
4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenol

Guidance literature:: With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; chloroform; at 20 ℃; for 0.166667h;
DOI:10.1016/j.tet.2013.06.064

Reference yield:

: 19614-12-1
2-bromo-5-methoxybenzyl bromide

: 1448000-73-4
4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 2 h / Reflux

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

2.2: 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

4.1: toluene / 2 h / 0 °C

5.1: benzene / 24 h / 100 °C

6.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

6.2: 24 h / 0 °C

7.1: toluene-4-sulfonic acid hydrazide; sodium hydrogencarbonate / 2-ethoxy-ethanol / 3 h / 135 °C

8.1: 10 wt% Pd(OH)2 on carbon; hydrogen / chloroform; methanol / 0.17 h / 20 °C

With lithium aluminium tetrahydride; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; methanol; 2-ethoxy-ethanol; chloroform; toluene; benzene; 5.1: |Arbuzov Reaction;
DOI:10.1016/j.tet.2013.06.064

Reference yield:

: 1448000-67-6
(E)-methyl 3-(4-(2-bromo-5-methoxystyryl)phenoxy)-4-methoxybenzoate

: 1448000-73-4
4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.1: toluene / 2 h / 0 °C

3.1: benzene / 24 h / 100 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

4.2: 24 h / 0 °C

5.1: toluene-4-sulfonic acid hydrazide; sodium hydrogencarbonate / 2-ethoxy-ethanol / 3 h / 135 °C

6.1: 10 wt% Pd(OH)2 on carbon; hydrogen / chloroform; methanol / 0.17 h / 20 °C

With lithium aluminium tetrahydride; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; methanol; 2-ethoxy-ethanol; chloroform; toluene; benzene; 3.1: |Arbuzov Reaction;
DOI:10.1016/j.tet.2013.06.064