4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenyl trifluoromethanesulfonate

Base Information

Chemical Name:4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenyl trifluoromethanesulfonate
CAS No.:1448000-74-5
Molecular Formula:C₃₃H₃₂BrF₃O₈S
Molecular Weight:725.577
Hs Code.:

Synonyms:4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenyl trifluoromethanesulfonate

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Chemical Property of 4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenyl trifluoromethanesulfonate

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Technology Process of 4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenyl trifluoromethanesulfonate

There total 15 articles about 4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1448000-73-4
4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenol

: 1448000-74-5
4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenyl trifluoromethanesulfonate

Guidance literature:: With dmap; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1016/j.tet.2013.06.064

Reference yield:

: 135303-87-6
methyl 3-(4'-formylphenoxy)-4-methoxybenzoate

: 1448000-74-5
4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

3.1: toluene / 2 h / 0 °C

4.1: benzene / 24 h / 100 °C

5.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

5.2: 24 h / 0 °C

6.1: toluene-4-sulfonic acid hydrazide; sodium hydrogencarbonate / 2-ethoxy-ethanol / 3 h / 135 °C

7.1: 10 wt% Pd(OH)2 on carbon; hydrogen / chloroform; methanol / 0.17 h / 20 °C

8.1: dmap / dichloromethane / 1 h / -78 °C

With dmap; lithium aluminium tetrahydride; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; methanol; 2-ethoxy-ethanol; dichloromethane; chloroform; toluene; benzene; 4.1: |Arbuzov Reaction;
DOI:10.1016/j.tet.2013.06.064

Reference yield:

: 1448000-67-6
(E)-methyl 3-(4-(2-bromo-5-methoxystyryl)phenoxy)-4-methoxybenzoate

: 1448000-74-5
4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-(methoxymethoxy)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.1: toluene / 2 h / 0 °C

3.1: benzene / 24 h / 100 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

4.2: 24 h / 0 °C

5.1: toluene-4-sulfonic acid hydrazide; sodium hydrogencarbonate / 2-ethoxy-ethanol / 3 h / 135 °C

6.1: 10 wt% Pd(OH)2 on carbon; hydrogen / chloroform; methanol / 0.17 h / 20 °C

7.1: dmap / dichloromethane / 1 h / -78 °C

With dmap; lithium aluminium tetrahydride; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; methanol; 2-ethoxy-ethanol; dichloromethane; chloroform; toluene; benzene; 3.1: |Arbuzov Reaction;
DOI:10.1016/j.tet.2013.06.064