N⁶-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Base Information

• Chemical Name: N⁶-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine
• CAS No.: 329188-17-2
• Molecular Formula: C₄₀H₅₇N₅O₁₃Si₂
• Molecular Weight: 872.089
• Mol file: 329188-17-2.mol

Synonyms:N⁶-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Chemical Property of N⁶-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

There total 1 articles about N⁶-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N6-benzoyladenosine (79154-57-7) + 1,2,3,5-tetraacetylribose (13035-61-5) → N6-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine (329188-17-2)

Guidance literature:

With tin(IV) chloride; In 1,2-dichloro-ethane; at 0 ℃;

DOI:10.1080/15257779908041519

Reference yield: 82.0%

N6-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine (329188-17-2) → N6-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine (329188-20-7)

Guidance literature:

With sodium methylate; In methanol; for 0.166667h;

DOI:10.1080/15257779908041519

Reference yield:

N6-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine (329188-17-2) → N-[9-(3-{3,4-dihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yloxy}-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / NaOMe / methanol / 0.17 h / 20 °C

2: pyridine / 16 h / 20 °C

With sodium methylate; In pyridine; methanol;

DOI:10.1080/15257770008045465

upstream raw materials:

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine

1,2,3,5-tetraacetylribose

Downstream raw materials:

N⁶-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine