benzyl (S)-1-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethylcarbamoyl)-2 phenylethylcarbamate

Base Information

Chemical Name:benzyl (S)-1-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethylcarbamoyl)-2 phenylethylcarbamate
CAS No.:1273502-82-1
Molecular Formula:C₂₈H₂₉N₃O₄
Molecular Weight:471.556
Hs Code.:

Synonyms:benzyl (S)-1-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethylcarbamoyl)-2 phenylethylcarbamate

Suppliers and Price of benzyl (S)-1-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethylcarbamoyl)-2 phenylethylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl (S)-1-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethylcarbamoyl)-2 phenylethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl (S)-1-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethylcarbamoyl)-2 phenylethylcarbamate

There total 3 articles about benzyl (S)-1-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethylcarbamoyl)-2 phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 915018-73-4
2-amino-1-(3,4-dihydroquinolin-1(2H)-yl)ethanone

: 1161-13-3
N-Cbz-L-Phe

: 1273502-82-1
benzyl (S)-1-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethylcarbamoyl)-2 phenylethylcarbamate

Guidance literature:: 2-amino-1-(3,4-dihydroquinolin-1(2H)-yl)ethanone; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

N-Cbz-L-Phe; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1039/c0ob00628a

Reference yield:

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 1273502-82-1
benzyl (S)-1-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethylcarbamoyl)-2 phenylethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 0.17 h / -20 °C / Inert atmosphere

1.2: 0.25 h / -20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

3.2: 0.17 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/c0ob00628a

Reference yield:

: benzyl [2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl]carbamate

: 1273502-82-1
benzyl (S)-1-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethylcarbamoyl)-2 phenylethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

2.2: 0.17 h / 0 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1039/c0ob00628a