4-[2-chloromethyl-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-[2-chloromethyl-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
• CAS No.: 474330-38-6
• Molecular Formula: C₂₅H₂₇ClF₃NO₃
• Molecular Weight: 481.942

Synonyms:4-[2-chloromethyl-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-[2-chloromethyl-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of 4-[2-chloromethyl-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-[2-chloromethyl-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

4-[2-hydroxymethyl-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (474330-37-5) + methanesulfonyl chloride (124-63-0) → 4-[2-chloromethyl-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (474330-38-6)

Guidance literature:

With pyridine; triethylamine; In hexane; dichloromethane; ethyl acetate;

Reference yield:

2-bromo-1,3-bis(2-trifluoromethylphenoxymethyl)benzene (474330-30-8) + 4-[2-chloromethyl-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (474330-38-6) + 4-Phenylphenol (92-69-3) → 4-[2-(biphenyl-4-yloxymethyl)-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (474330-39-7)

Guidance literature:

With potassium carbonate; In acetone;

Reference yield:

4-[4-bromo-2-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (474330-47-7) + 4-[2-chloromethyl-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (474330-38-6) + 4-[2-(biphenyl-4-yloxymethyl)-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (474330-39-7) → 4-(4-Bromo-2-hydroxymethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl Ester (474330-48-8) + 4-(4-Bromo-2-chloromethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (474330-49-9)

Guidance literature:

upstream raw materials:

4-[2-hydroxymethyl-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

methanesulfonyl chloride

Downstream raw materials:

4-[2-(biphenyl-4-yloxymethyl)-5-(2-trifluoromethyl-phenoxymethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

4-(4-Bromo-2-hydroxymethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl Ester

4-(4-Bromo-2-chloromethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

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