2-[5-benzyloxy-3',6'-dihydro-2'H-[2,4'-bipyridine]-1'-yl]-N-(3-methylphenyl)acetamide

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Chemical Name:2-[5-benzyloxy-3',6'-dihydro-2'H-[2,4'-bipyridine]-1'-yl]-N-(3-methylphenyl)acetamide
CAS No.:630121-02-7
Molecular Formula:C₂₆H₂₇N₃O₂
Molecular Weight:413.519
Hs Code.:

Synonyms:2-[5-benzyloxy-3',6'-dihydro-2'H-[2,4'-bipyridine]-1'-yl]-N-(3-methylphenyl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[5-benzyloxy-3',6'-dihydro-2'H-[2,4'-bipyridine]-1'-yl]-N-(3-methylphenyl)acetamide

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Technology Process of 2-[5-benzyloxy-3',6'-dihydro-2'H-[2,4'-bipyridine]-1'-yl]-N-(3-methylphenyl)acetamide

There total 10 articles about 2-[5-benzyloxy-3',6'-dihydro-2'H-[2,4'-bipyridine]-1'-yl]-N-(3-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 630121-01-6
5-(benzyloxy)-1',2',3',6'-tetrahydro-2,4'-bipyridine

: 5439-17-8
2-bromo-N-(3-methylphenyl)acetamide

: 630121-02-7
2-[5-benzyloxy-3',6'-dihydro-2'H-[2,4'-bipyridine]-1'-yl]-N-(3-methylphenyl)acetamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm060662k

Reference yield: 55.0%

: 630121-02-7
2-[5-benzyloxy-3',6'-dihydro-2'H-[2,4'-bipyridine]-1'-yl]-N-(3-methylphenyl)acetamide

Guidance literature:

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 630121-02-7
2-[5-benzyloxy-3',6'-dihydro-2'H-[2,4'-bipyridine]-1'-yl]-N-(3-methylphenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

1.2: 68 percent / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

2.1: 55 percent / K₂CO₃ / dimethylformamide / 18 h / 20 °C

With n-butyllithium; potassium carbonate; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm060662k