5-(Benzyloxy)-2-bromopyridine

Base Information

• Chemical Name: 5-(Benzyloxy)-2-bromopyridine
• CAS No.: 630120-99-9
• Molecular Formula: C12H10BrNO
• Molecular Weight: 264.121
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID70582429
• Nikkaji Number: J2.672.242J
• Wikidata: Q82473851
• Mol file: 630120-99-9.mol

Synonyms:5-(Benzyloxy)-2-bromopyridine;630120-99-9;5-Benzyloxy-2-bromopyridine;2-bromo-5-phenylmethoxypyridine;HDH-PHARMA 24754;MFCD11874623;Pyridine, 2-bromo-5-(phenylmethoxy)-;HDH-PHARMA;5-Benzyloxy-2-bromo-pyridine;SCHEMBL1103901;DTXSID70582429;KKCMCYRLJVVNTQ-UHFFFAOYSA-N;AKOS022176090;2-bromo-5-[(phenylmethyl)oxy]pyridine;DS-7683;MB10387;SY111458;CS-0046861;A868273

Chemical Property of 5-(Benzyloxy)-2-bromopyridine

Chemical Property:

• Boiling Point: 366.5±27.0 °C(Predicted)
• PKA: -2.25±0.10(Predicted)
• PSA: 22.12000
• Density: 1.438±0.06 g/cm3(Predicted)
• LogP: 3.42310
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 262.99458
• Heavy Atom Count: 15
• Complexity: 183

Purity/Quality:

97% ^*data from raw suppliers

5-(Benzyloxy)-2-bromopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CN=C(C=C2)Br

Technology Process of 5-(Benzyloxy)-2-bromopyridine

There total 10 articles about 5-(Benzyloxy)-2-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

6-bromo-pyridin-3-ol (55717-45-8,55717-40-3) + benzyl bromide (100-39-0) → 5-(benzyloxy)-2-bromopyridine (630120-99-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 6h;

Reference yield: 77.0%

6-bromo-pyridin-3-ol (55717-45-8,55717-40-3) + benzyl chloride (100-44-7) → 5-(benzyloxy)-2-bromopyridine (630120-99-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.3987/COM-11-12239

Reference yield: 66.0%

6-bromo-pyridin-3-ol (55717-45-8,55717-40-3) + benzyl alcohol (100-51-6,185532-71-2) → 5-(benzyloxy)-2-bromopyridine (630120-99-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 35 ℃; for 18h;

upstream raw materials:

5-(benzyloxy)-2-chloropyridine

6-chloropyridine-3-ol

benzyl bromide

trimethylsilyl bromide

Downstream raw materials:

5-(benzyloxy)-1',2',3',6'-tetrahydro-2,4'-bipyridine

2-[5-benzyloxy-3',6'-dihydro-2'H-[2,4'-bipyridine]-1'-yl]-N-(3-methylphenyl)acetamide

tert-butyl{1-[5-(benzyloxy)pyridin-2-yl]piperidin-4-yl}carbamate

tert-butyl 5-(benzyloxy)-3',6'-dihydro-2,4'-bipyridine-1'(2'H)-carboxylate