2-(morpholin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidin-4-yl 4-methylbenzenesulfonate

Base Information

Chemical Name:2-(morpholin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidin-4-yl 4-methylbenzenesulfonate
CAS No.:1452776-72-5
Molecular Formula:C₂₁H₂₃N₃O₄S₂
Molecular Weight:445.563
Hs Code.:

Synonyms:2-(morpholin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidin-4-yl 4-methylbenzenesulfonate

Suppliers and Price of 2-(morpholin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidin-4-yl 4-methylbenzenesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(morpholin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidin-4-yl 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(morpholin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidin-4-yl 4-methylbenzenesulfonate

There total 4 articles about 2-(morpholin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidin-4-yl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 53074-05-8
2-(morpholin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidin-4(3H)-one

: 98-59-9
p-toluenesulfonyl chloride

: 1452776-72-5
2-(morpholin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidin-4-yl 4-methylbenzenesulfonate

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h; regioselective reaction;
DOI:10.1021/jo4010876

Reference yield:

: 1481962-03-1
2-(methylsulfonyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidin-4(3H)-one

: 1452776-72-5
2-(morpholin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidin-4-yl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 18.5 h / 160 °C

2: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 3 h / 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jo4010876

Reference yield:

: 51550-17-5
5,6,7,8-tetrahydro-2-(methylthio)<1>benzothieno<2,3-d>pyrimidin-4(1H)-one

: 1452776-72-5
2-(morpholin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidin-4-yl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: dihydrogen peroxide / acetic acid / 5 h / 45 °C

2: 18.5 h / 160 °C

3: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 3 h / 20 °C

With dmap; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetic acid;
DOI:10.1021/jo4010876