3-(tert-butyldimethylsilyloxymethyl)-5-[3-(2,6-dimethyl-4-phenylphenyloxy)propyl]isoxazole

Base Information

Chemical Name:3-(tert-butyldimethylsilyloxymethyl)-5-[3-(2,6-dimethyl-4-phenylphenyloxy)propyl]isoxazole
CAS No.:743476-80-4
Molecular Formula:C₂₇H₃₇NO₃Si
Molecular Weight:451.681
Hs Code.:

Synonyms:3-(tert-butyldimethylsilyloxymethyl)-5-[3-(2,6-dimethyl-4-phenylphenyloxy)propyl]isoxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(tert-butyldimethylsilyloxymethyl)-5-[3-(2,6-dimethyl-4-phenylphenyloxy)propyl]isoxazole

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Technology Process of 3-(tert-butyldimethylsilyloxymethyl)-5-[3-(2,6-dimethyl-4-phenylphenyloxy)propyl]isoxazole

There total 4 articles about 3-(tert-butyldimethylsilyloxymethyl)-5-[3-(2,6-dimethyl-4-phenylphenyloxy)propyl]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 72774-04-0
3,5‐dimethyl‐[1,1'‐biphenyl]‐4‐ol

: 153168-61-7
3-<<oxy>methyl>-5-isoxazolepropanol

: 743476-80-4
3-(tert-butyldimethylsilyloxymethyl)-5-[3-(2,6-dimethyl-4-phenylphenyloxy)propyl]isoxazole

Guidance literature:: DOI:10.1071/CH03295

Reference yield:

: 591-50-4
iodobenzene

: 743476-80-4
3-(tert-butyldimethylsilyloxymethyl)-5-[3-(2,6-dimethyl-4-phenylphenyloxy)propyl]isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: boron tribromide / dichloromethane / -78 - 20 °C

2.2: 0 °C

With tert.-butyl lithium; boron tribromide; In tetrahydrofuran; dichloromethane; pentane; 3.1: Mitsunobu reaction;

Reference yield:

: 14804-38-7
5-bromo-2-methoxy-1,3-dimethylbenzene

: 743476-80-4
3-(tert-butyldimethylsilyloxymethyl)-5-[3-(2,6-dimethyl-4-phenylphenyloxy)propyl]isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: boron tribromide / dichloromethane / -78 - 20 °C

2.2: 0 °C

With tert.-butyl lithium; boron tribromide; In tetrahydrofuran; dichloromethane; pentane; 3.1: Mitsunobu reaction;