72774-04-0

Upstream product

• 94001-39-5 4-methoxy-3,5-dimethyl-1,1'-biphenyl 
• 83638-58-8 3,5-dimethyl-1,1'-biphenyl-4-yl acetate 
• 71-43-2 benzene 
• 2374-05-2 4-bromo-2,6-dimethyl-phenol 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 14804-38-7 5-bromo-2-methoxy-1,3-dimethylbenzene 
• 94581-99-4 4-amino-2,6-dimethylphenyl acetate 
• 65359-76-4 acetic acid-(2,6-dimethyl-4-nitro-phenyl ester) 

Downstream Products

• 93434-45-8 2.6-Dimethyl-4-phenyl-2-acetoxy-cyclohexadien-(3.5)-on-⁽¹⁾ 
• 743476-80-4 3-(tert-butyldimethylsilyloxymethyl)-5-[3-(2,6-dimethyl-4-phenylphenyloxy)propyl]isoxazole 

Relevant academic research and scientific papers

Catalytic Activation of Unstrained C(Aryl)-C(Alkyl) Bonds in 2,2′-Methylenediphenols

Catalytic activation of unstrained and nonpolar C-C bonds remains a largely unmet challenge. Here, we describe our detailed efforts in developing a rhodium-catalyzed hydrogenolysis of unstrained C(aryl)-C(alkyl) bonds in 2,2′-methylenediphenols aided by removable directing groups. Good yields of the monophenol products are obtained with tolerating a wide range of functional groups. In addition, the reaction is scalable, and the catalyst loading can be reduced to as low as 0.5 mol %. Moreover, this method proves to be effective to cleave C(aryl)-C(alkyl) linkages in both models of phenolic resins and commercial novolacs resins. Finally, detailed experimental and computational mechanistic studies show that with C-H activation being a competitive but reversible off-cycle reaction, this transformation goes through a directed C(aryl)-C(alkyl) oxidative addition pathway.

Site-selective Oxidative Dearomatization of Phenols and Naphthols into ortho-Quinols or Epoxy ortho-Quinols using Oxone as the Source of Dimethyldioxirane

A novel reactivity of dimethyldioxirane, generated in situ from Oxone and acetone, with substituted phenols and naphthols is reported. This methodology allowed the synthesis of ortho-quinols or epoxy ortho-quinols from a site-selective oxidative dearomatization process, with good yields under very mild conditions. A short total synthesis of natural product lacinilene C methyl ether is also described using this process as the key step. (Figure presented.).

Tandem dienone photorearrangement-cycloaddition for the rapid generation of molecular complexity

A tandem dienone photorearrangement-cycloaddition (DPC) reaction of novel cyclohexadienone substrates tethered with various 2π and 4π reaction partners resulted in the formation of polycyclic, bridged frameworks. In particular, use of alkynyl ether-tether

Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies

To develop potent and highly selective transthyretin (TTR) amyloidogenesis inhibitors, it is useful to systematically optimize the three substructural elements that compose a typical TTR kinetic stabilizer: the two aryl rings and the linker joining them. Herein, we evaluated 40 bisaryl molecules based on 10 unique linker substructures to determine how these linkages influence inhibitor potency and selectivity. These linkers connect one unsubstituted aromatic ring to either a 3,5-X2 or a 3,5-X2-4-OH phenyl substructure (X = Br or CH3). Coconsideration of amyloid inhibition and ex vivo plasma TTR binding selectivity data reveal that direct connection of the two aryls or linkage through nonpolar E-olefin or -CH2CH2- substructures generates the most potent and selective TTR amyloidogenesis inhibitors exhibiting minimal undesirable binding to the thyroid hormone nuclear receptor or the COX-1 enzyme. Five high-resolution TTR·inhibitor crystal structures (1.4-1.8 A?) provide insight into why such linkers afford inhibitors with greater potency and selectivity.

Antiviral agents

This invention relates to a compound capable of binding to a picornavirus capsid comprising two or more capsid binding moieties.