N-{4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butyl}-2-({4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butylcarbamoyl}-methyl)-2-hydroxy-succinamic acid tert-butyl ester

Base Information

Chemical Name:N-{4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butyl}-2-({4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butylcarbamoyl}-methyl)-2-hydroxy-succinamic acid tert-butyl ester
CAS No.:705282-08-2
Molecular Formula:C₆₈H₈₆N₆O₁₁
Molecular Weight:1163.46
Hs Code.:

<i>N</i>-{4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butyl}-2-({4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butylcarbamoyl}-methyl)-2-hydroxy-succinamic acid <i>tert</i>-butyl ester

Synonyms:N-{4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butyl}-2-({4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butylcarbamoyl}-methyl)-2-hydroxy-succinamic acid tert-butyl ester

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Chemical Property of N-{4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butyl}-2-({4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butylcarbamoyl}-methyl)-2-hydroxy-succinamic acid tert-butyl ester

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-{4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butyl}-2-({4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butylcarbamoyl}-methyl)-2-hydroxy-succinamic acid tert-butyl ester

There total 10 articles about N-{4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butyl}-2-({4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butylcarbamoyl}-methyl)-2-hydroxy-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114340-53-3
2-tert-butyl-1,3-di-N-(hydroxyl) succinimidyl citrate

: N-[3-(4-aminobutylamino)butyl]-2,5-bis(benzyloxy)carbamate trifluoroacetic acid salt (1:2)

: 705282-08-2
N-{4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butyl}-2-({4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butylcarbamoyl}-methyl)-2-hydroxy-succinamic acid tert-butyl ester

Guidance literature:: With triethylamine; In 1,4-dioxane; dichloromethane; at 20 ℃;
DOI:10.1021/jo049803l

Reference yield:

: 303-38-8
2,3-Dihydroxybenzoic acid

: 705282-08-2
N-{4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butyl}-2-({4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butylcarbamoyl}-methyl)-2-hydroxy-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃*1.5H₂O / acetone / 24 h / Heating

2: 3.11 g / NaOH / H₂O; methanol / 3 h / Heating

3: oxalyl chloride; DMF / hexane; CH₂Cl₂ / 0.5 h / 0 °C

4: 86 percent / NaOH / CH₂Cl₂; H₂O / 3 h / 20 °C

5: CH₂Cl₂ / 3 h / 20 °C

6: 0.237 g / triethylamine / dioxane; CH₂Cl₂ / 20 °C

With sodium hydroxide; oxalyl dichloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; hexane; dichloromethane; water; acetone;
DOI:10.1021/jo049803l

Reference yield:

: 74272-78-9
2,3-dibenzyloxybenzoic acid

: 705282-08-2
N-{4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butyl}-2-({4-[4-(2,3-bis-benzyloxy-benzoylamino)-butylamino]-butylcarbamoyl}-methyl)-2-hydroxy-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride; DMF / hexane; CH₂Cl₂ / 0.5 h / 0 °C

2: 86 percent / NaOH / CH₂Cl₂; H₂O / 3 h / 20 °C

3: CH₂Cl₂ / 3 h / 20 °C

4: 0.237 g / triethylamine / dioxane; CH₂Cl₂ / 20 °C

With sodium hydroxide; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; hexane; dichloromethane; water;
DOI:10.1021/jo049803l