(-)-(S)-1-(tert-butyldimethylsilyloxy)-4-(N,N-dibenzylamino)-5-(triphenylmethoxy)pentane

Base Information

Chemical Name:(-)-(S)-1-(tert-butyldimethylsilyloxy)-4-(N,N-dibenzylamino)-5-(triphenylmethoxy)pentane
CAS No.:253882-16-5
Molecular Formula:C₄₄H₅₃NO₂Si
Molecular Weight:655.996
Hs Code.:

Synonyms:(-)-(S)-1-(tert-butyldimethylsilyloxy)-4-(N,N-dibenzylamino)-5-(triphenylmethoxy)pentane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-(S)-1-(tert-butyldimethylsilyloxy)-4-(N,N-dibenzylamino)-5-(triphenylmethoxy)pentane

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Technology Process of (-)-(S)-1-(tert-butyldimethylsilyloxy)-4-(N,N-dibenzylamino)-5-(triphenylmethoxy)pentane

There total 1 articles about (-)-(S)-1-(tert-butyldimethylsilyloxy)-4-(N,N-dibenzylamino)-5-(triphenylmethoxy)pentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 76-83-5
trityl chloride

: 205068-04-8
(S)-2-(N,N-dibenzylamino)-5-(tert-butyldimethylsilyloxy)pentan-1-ol

: 253882-16-5
(-)-(S)-1-(tert-butyldimethylsilyloxy)-4-(N,N-dibenzylamino)-5-(triphenylmethoxy)pentane

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 36h;
DOI:10.1021/jo991095u

Reference yield: 100.0%

: 253882-16-5
(-)-(S)-1-(tert-butyldimethylsilyloxy)-4-(N,N-dibenzylamino)-5-(triphenylmethoxy)pentane

: (-)-(S)-4-(N,N-dibenzylamino)-5-(triphenylmethoxy)-1-pentanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h;
DOI:10.1021/jo991095u

Reference yield:

: 253882-16-5
(-)-(S)-1-(tert-butyldimethylsilyloxy)-4-(N,N-dibenzylamino)-5-(triphenylmethoxy)pentane

: 253882-20-1
(+)-(S)-6,6-dibromo-4-(N,N-dibenzylamino)-5-hexenyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / TBAF / tetrahydrofuran; diethyl ether / 2 h / 20 °C

2: 87 percent / NaH / tetrahydrofuran / Heating

3: 78 percent / TFA / methanol; CH₂Cl₂ / 0.5 h / 20 °C

4: 96 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

5: 93 percent / PPh₃ / CH₂Cl₂ / 1 h / 0 °C

With oxalyl dichloride; tetrabutyl ammonium fluoride; sodium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1: Substitution / 2: Acylation / 3: Hydrolysis / 4: Swern oxidation / 5: Substitution;
DOI:10.1021/jo991095u