t-butyl 3-(4-benzyloxy-3-methoxybenzylcarbamoyl)-azetidine-1-carboxylate

Base Information

Chemical Name:t-butyl 3-(4-benzyloxy-3-methoxybenzylcarbamoyl)-azetidine-1-carboxylate
CAS No.:1193988-62-3
Molecular Formula:C₂₄H₃₀N₂O₅
Molecular Weight:426.513
Hs Code.:

Synonyms:t-butyl 3-(4-benzyloxy-3-methoxybenzylcarbamoyl)-azetidine-1-carboxylate

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Chemical Property of t-butyl 3-(4-benzyloxy-3-methoxybenzylcarbamoyl)-azetidine-1-carboxylate

Chemical Property:

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Technology Process of t-butyl 3-(4-benzyloxy-3-methoxybenzylcarbamoyl)-azetidine-1-carboxylate

There total 2 articles about t-butyl 3-(4-benzyloxy-3-methoxybenzylcarbamoyl)-azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100955-81-5
(4-(benzyloxy)-3-methoxyphenyl)methanamine hydrochloride

: 142253-55-2
1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid

: 1193988-62-3
t-butyl 3-(4-benzyloxy-3-methoxybenzylcarbamoyl)-azetidine-1-carboxylate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1193988-62-3
t-butyl 3-(4-benzyloxy-3-methoxybenzylcarbamoyl)-azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / water; tetrahydrofuran / 20 h / 20 °C / Cooling with ice

1.2: pH 4

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h / 20 °C

With potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1193988-62-3
t-butyl 3-(4-benzyloxy-3-methoxybenzylcarbamoyl)-azetidine-1-carboxylate

: 1193988-63-4
N-(4-benzyloxy-3-methoxybenzyl)-3-azetidinecarboxamide

Guidance literature:: t-butyl 3-(4-benzyloxy-3-methoxybenzylcarbamoyl)-azetidine-1-carboxylate; With trifluoroacetic acid; In hexane; dichloromethane; ethyl acetate; at 20 ℃; for 1.5h; Cooling with ice;

In dichloromethane; water; Neutralization;