2-(benzyloxy)-3,5-dimethoxy-6-<2-(methoxycarbonyl)-1-pyrrolidinyl>-4-methylphenylacetaldehyde

Base Information

Chemical Name:2-(benzyloxy)-3,5-dimethoxy-6-<2-(methoxycarbonyl)-1-pyrrolidinyl>-4-methylphenylacetaldehyde
CAS No.:81457-20-7
Molecular Formula:C₂₄H₂₉NO₆
Molecular Weight:427.497
Hs Code.:

Synonyms:2-(benzyloxy)-3,5-dimethoxy-6-<2-(methoxycarbonyl)-1-pyrrolidinyl>-4-methylphenylacetaldehyde

Suppliers and Price of 2-(benzyloxy)-3,5-dimethoxy-6-<2-(methoxycarbonyl)-1-pyrrolidinyl>-4-methylphenylacetaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(benzyloxy)-3,5-dimethoxy-6-<2-(methoxycarbonyl)-1-pyrrolidinyl>-4-methylphenylacetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(benzyloxy)-3,5-dimethoxy-6-<2-(methoxycarbonyl)-1-pyrrolidinyl>-4-methylphenylacetaldehyde

There total 13 articles about 2-(benzyloxy)-3,5-dimethoxy-6-<2-(methoxycarbonyl)-1-pyrrolidinyl>-4-methylphenylacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 43041-12-9,52183-82-1,2577-48-2
methyl pyrrolidine-2-carboxylate

: 81457-20-7
2-(benzyloxy)-3,5-dimethoxy-6-<2-(methoxycarbonyl)-1-pyrrolidinyl>-4-methylphenylacetaldehyde

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) copper acetate monohydrate, oxygen / 1.) methanol, room temp., 10 min

2: 1.) 1 M aq. Na₂S₂O₄ (pH 7.0), 2.) Na₂S₂O₄ / 1.) 3-pentanone, 15 min, 2.) reflux, 105 min

3: K₂CO₃ / various solvent(s) / 1.5 h / Heating

4: various solvent(s) / 41 h

5: 83 percent / barium hydroxide octahydrate / dimethylformamide / 32 h / Ambient temperature

6: 96 percent / H₂ / 5percent Pd/C / methanol / 42 h / 2585.7 Torr

7: 100 percent / K₂CO₃ / dimethylformamide / 10.5 h

8: 61 percent / various solvent(s) / 2.5 h / Heating

9: 84 percent / anhydrous K₂CO₃ / acetonitrile / 24 h

10: 33 percent / 1percent aq. osmium tetraoxide, NaIO₄ / diethyl ether / 16 h / Ambient temperature

With sodium periodate; osmium(VIII) oxide; sodium dithionite; barium hydroxide octahydrate; hydrogen; oxygen; copper (I) acetate; potassium carbonate; palladium on activated charcoal; In methanol; diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00133a034

Reference yield:

: 2207-57-0
2-methoxy-3-methyl-1,4-benzoquinone

: 81457-20-7
2-(benzyloxy)-3,5-dimethoxy-6-<2-(methoxycarbonyl)-1-pyrrolidinyl>-4-methylphenylacetaldehyde

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) copper acetate monohydrate, oxygen / 1.) methanol, room temp., 10 min

2: 1.) 1 M aq. Na₂S₂O₄ (pH 7.0), 2.) Na₂S₂O₄ / 1.) 3-pentanone, 15 min, 2.) reflux, 105 min

3: K₂CO₃ / various solvent(s) / 1.5 h / Heating

4: various solvent(s) / 41 h

5: 83 percent / barium hydroxide octahydrate / dimethylformamide / 32 h / Ambient temperature

6: 96 percent / H₂ / 5percent Pd/C / methanol / 42 h / 2585.7 Torr

7: 100 percent / K₂CO₃ / dimethylformamide / 10.5 h

8: 61 percent / various solvent(s) / 2.5 h / Heating

9: 84 percent / anhydrous K₂CO₃ / acetonitrile / 24 h

10: 33 percent / 1percent aq. osmium tetraoxide, NaIO₄ / diethyl ether / 16 h / Ambient temperature

With sodium periodate; osmium(VIII) oxide; sodium dithionite; barium hydroxide octahydrate; hydrogen; oxygen; copper (I) acetate; potassium carbonate; palladium on activated charcoal; In methanol; diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00133a034

Reference yield:

: 81457-00-3
2-methoxy-3-methyl-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-1,4-benzoquinone

: 81457-20-7
2-(benzyloxy)-3,5-dimethoxy-6-<2-(methoxycarbonyl)-1-pyrrolidinyl>-4-methylphenylacetaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) 1 M aq. Na₂S₂O₄ (pH 7.0), 2.) Na₂S₂O₄ / 1.) 3-pentanone, 15 min, 2.) reflux, 105 min

2: K₂CO₃ / various solvent(s) / 1.5 h / Heating

3: various solvent(s) / 41 h

4: 83 percent / barium hydroxide octahydrate / dimethylformamide / 32 h / Ambient temperature

5: 96 percent / H₂ / 5percent Pd/C / methanol / 42 h / 2585.7 Torr

6: 100 percent / K₂CO₃ / dimethylformamide / 10.5 h

7: 61 percent / various solvent(s) / 2.5 h / Heating

8: 84 percent / anhydrous K₂CO₃ / acetonitrile / 24 h

9: 33 percent / 1percent aq. osmium tetraoxide, NaIO₄ / diethyl ether / 16 h / Ambient temperature

With sodium periodate; osmium(VIII) oxide; sodium dithionite; barium hydroxide octahydrate; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00133a034