5'H-1,3-dibenzyl-6',7'-dihydro-1'-methylspiro(imidazolidin-5,4'-indole)-2,4-dione

Base Information

• Chemical Name: 5'H-1,3-dibenzyl-6',7'-dihydro-1'-methylspiro(imidazolidin-5,4'-indole)-2,4-dione
• CAS No.: 905278-28-6
• Molecular Formula: C₂₅H₂₅N₃O₂
• Molecular Weight: 399.492
• Mol file: 905278-28-6.mol

Synonyms:5'H-1,3-dibenzyl-6',7'-dihydro-1'-methylspiro(imidazolidin-5,4'-indole)-2,4-dione

Chemical Property of 5'H-1,3-dibenzyl-6',7'-dihydro-1'-methylspiro(imidazolidin-5,4'-indole)-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'H-1,3-dibenzyl-6',7'-dihydro-1'-methylspiro(imidazolidin-5,4'-indole)-2,4-dione

There total 2 articles about 5'H-1,3-dibenzyl-6',7'-dihydro-1'-methylspiro(imidazolidin-5,4'-indole)-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

5'H,6',7'-dihydro-1'-methylspiro(hydantoin-5,4'-indole) (905278-20-8) + benzyl bromide (100-39-0) → 5'H-3-benzyl-6',7'-dihydro-1'-methylspiro(imidazolidin-5,4'-indole)-2,4-dione (905278-29-7) + 5'H-1,3-dibenzyl-6',7'-dihydro-1'-methylspiro(imidazolidin-5,4'-indole)-2,4-dione (905278-28-6)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; potassium iodide; In toluene; for 24h; Heating;

DOI:10.1021/jo060616s

Reference yield:

1-methyl-1,5,6,7-tetrahydro-indol-4-one (51471-08-0) → 5'H-1,3-dibenzyl-6',7'-dihydro-1'-methylspiro(imidazolidin-5,4'-indole)-2,4-dione (905278-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 21 percent / ethanol; H₂O / 55 - 60 °C

2: 26 percent / 18-crown-6; K₂CO₃; KI / toluene / 24 h / Heating

With 18-crown-6 ether; potassium carbonate; potassium iodide; In ethanol; water; toluene; 1: Bucherer-Bergs reaction;

DOI:10.1021/jo060616s

Reference yield: 99.0%

5'H-1,3-dibenzyl-6',7'-dihydro-1'-methylspiro(imidazolidin-5,4'-indole)-2,4-dione (905278-28-6) → C25H27N3O2 (905278-37-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; Heating;

DOI:10.1021/jo060616s

upstream raw materials:

5'H,6',7'-dihydro-1'-methylspiro(hydantoin-5,4'-indole)

benzyl bromide

1-methyl-1,5,6,7-tetrahydro-indol-4-one

Downstream raw materials:

C₂₅H₂₇N₃O₂