benzaldehyde (4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)hydrazone

Base Information

• Chemical Name: benzaldehyde (4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)hydrazone
• CAS No.: 3318-07-8
• Molecular Formula: C₂₁H₁₆N₄O
• Molecular Weight: 340.384
• Mol file: 3318-07-8.mol

Synonyms:benzaldehyde (4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)hydrazone

Chemical Property of benzaldehyde (4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)hydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of benzaldehyde (4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)hydrazone

There total 7 articles about benzaldehyde (4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzaldehyde (100-52-7) + 2-hydrazino-3-phenyl-3H-quinazolin-4-one (731-52-2) → benzaldehyde (4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)hydrazone (3318-07-8)

Guidance literature:

With acetic acid; In ethanol; for 3h; Reflux;

DOI:10.1002/jhet.5570450642

Reference yield:

3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one (18741-24-7) → benzaldehyde (4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)hydrazone (3318-07-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / sodium hydroxide / aq. ethanol / 1 h

2: 81 percent / hydrazine hydrate; potassium carbonate / ethanol / 22 h / Heating

3: 76 percent / glacial acetic acid / 33 h / Heating

With sodium hydroxide; potassium carbonate; hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1016/j.bmc.2006.09.065

Reference yield:

2-methylmercapto-3-phenyl-4(3H)-quinazolinone (73987-32-3) → benzaldehyde (4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)hydrazone (3318-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / hydrazine hydrate; potassium carbonate / ethanol / 22 h / Heating

2: 76 percent / glacial acetic acid / 33 h / Heating

With potassium carbonate; hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1016/j.bmc.2006.09.065

upstream raw materials:

benzaldehyde

2-hydrazino-3-phenyl-3H-quinazolin-4-one

3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

2-methylmercapto-3-phenyl-4(3H)-quinazolinone

Downstream raw materials:

1,4-diphenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one