Boc-Thr(OBn)-Lys(2Cl,Z)ψPro-Arg(Tos)-OBn

Base Information

Chemical Name:Boc-Thr(OBn)-Lys(2Cl,Z)ψPro-Arg(Tos)-OBn
CAS No.:154508-98-2
Molecular Formula:C₅₅H₇₁ClN₈O₁₁S₂
Molecular Weight:1119.8
Hs Code.:

Boc-Thr(OBn)-Lys(2Cl,Z)ψ<CSNH>Pro-Arg(Tos)-OBn

Synonyms:Boc-Thr(OBn)-Lys(2Cl,Z)ψPro-Arg(Tos)-OBn

Suppliers and Price of Boc-Thr(OBn)-Lys(2Cl,Z)ψPro-Arg(Tos)-OBn

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Boc-Thr(OBn)-Lys(2Cl,Z)ψPro-Arg(Tos)-OBn

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Boc-Thr(OBn)-Lys(2Cl,Z)ψPro-Arg(Tos)-OBn

There total 8 articles about Boc-Thr(OBn)-Lys(2Cl,Z)ψPro-Arg(Tos)-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15260-10-3
N-Boc-O-benzyl-L-threonine

: H-Lys(2Cl,Z)ψPro-Arg(Tos)-OBn

: 154508-98-2
Boc-Thr(OBn)-Lys(2Cl,Z)ψPro-Arg(Tos)-OBn

Guidance literature:: With dicyclohexyl-carbodiimide; benzotriazol-1-ol; In dimethylsulfoxide-d6; at 0 ℃; Yield given;
DOI:10.1016/S0040-4020(01)81544-1

Reference yield:

: 29388-63-4
H-Arg(Tos)-OBzl

: 154508-98-2
Boc-Thr(OBn)-Lys(2Cl,Z)ψPro-Arg(Tos)-OBn

Guidance literature:: Multi-step reaction with 5 steps

1: DCC / HOBt / dimethylformamide / 0 °C

2: 2.) NaHCO₃ / 1.) TFA, room temp., 1.5 hrs; 2.) water, dichloromethane, room temp, 0.5 hr

3: dimethylformamide / 1.) 0 deg C, 2.3 hrs; 2.) room temp.

4: 2.) NaHCO₃ / 1.) TFA, room temp., 1.5 hrs; 2.) water, dichloromethane, room temp, 0.5 hr

5: DCC / HOBt / dimethylsulfoxide-d6 / 0 °C

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; benzotriazol-1-ol; In dimethylsulfoxide-d6; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)81544-1

Reference yield:

: 13836-37-8
Boc-Arg(Tos)-OH

: 154508-98-2
Boc-Thr(OBn)-Lys(2Cl,Z)ψPro-Arg(Tos)-OBn

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) Cs₂CO₃ / 1.) water, MeOH; 2.) DMF, 8 hrs

2: 2.) NaHCO₃ / 1.) TFA, room temp., 1.5 hrs; 2.) water, dichloromethane, room temp, 0.5 hr

3: DCC / HOBt / dimethylformamide / 0 °C

4: 2.) NaHCO₃ / 1.) TFA, room temp., 1.5 hrs; 2.) water, dichloromethane, room temp, 0.5 hr

5: dimethylformamide / 1.) 0 deg C, 2.3 hrs; 2.) room temp.

6: 2.) NaHCO₃ / 1.) TFA, room temp., 1.5 hrs; 2.) water, dichloromethane, room temp, 0.5 hr

7: DCC / HOBt / dimethylsulfoxide-d6 / 0 °C

With sodium hydrogencarbonate; caesium carbonate; dicyclohexyl-carbodiimide; benzotriazol-1-ol; In dimethylsulfoxide-d6; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)81544-1