2-(4-Benzoylamino-1,2,3,4-tetrahydrocarbazol-2-yl)buttersaeure-methylester

Base Information

• Chemical Name: 2-(4-Benzoylamino-1,2,3,4-tetrahydrocarbazol-2-yl)buttersaeure-methylester
• CAS No.: 152563-97-8
• Molecular Formula: C₂₄H₂₆N₂O₃
• Molecular Weight: 390.482
• Mol file: 152563-97-8.mol

Synonyms:2-(4-Benzoylamino-1,2,3,4-tetrahydrocarbazol-2-yl)buttersaeure-methylester

Chemical Property of 2-(4-Benzoylamino-1,2,3,4-tetrahydrocarbazol-2-yl)buttersaeure-methylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Benzoylamino-1,2,3,4-tetrahydrocarbazol-2-yl)buttersaeure-methylester

There total 8 articles about 2-(4-Benzoylamino-1,2,3,4-tetrahydrocarbazol-2-yl)buttersaeure-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

benzoic acid anhydride (93-97-0) + 2-(4-Acetoxyimino-1,2,3,4-tetrahydrocarbazol-2-yl)buttersaeure-methylester (152563-94-5) → 2-(4-Benzoylamino-1,2,3,4-tetrahydrocarbazol-2-yl)buttersaeure-methylester (152563-97-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In dichloromethane; for 48h; under 760 Torr;

Reference yield:

dimethyl ethylmalonate (26717-67-9) → 2-(4-Benzoylamino-1,2,3,4-tetrahydrocarbazol-2-yl)buttersaeure-methylester (152563-97-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 68 percent / sodium methoxide / methanol / 18 h / Ambient temperature

2: 70 percent / acetic acid / 5 h / Heating

3: 53 percent / NaCl / dimethylsulfoxide; H₂O / 18 h / 160 - 170 °C

4: 41 percent / 2,3-dichloro-5,6-dicyano-p-benzoquinone / tetrahydrofuran; H₂O / 1 h / 0 °C

5: 80 percent / NH₂OH*HCl, NaOAc*3H₂O / methanol; H₂O / 6 h / Heating

6: 90 percent / tetrahydrofuran / 1 h / 25 °C

7: 69 percent / hydrogen / 10 percent Pd/C / CH₂Cl₂ / 48 h / 760 Torr

With hydroxylamine hydrochloride; hydrogen; sodium methylate; sodium acetate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; dimethyl sulfoxide;

Reference yield:

2-Ethyl-2-(3-oxocyclohexyl)malonsaeure-dimethylester (152563-84-3) → 2-(4-Benzoylamino-1,2,3,4-tetrahydrocarbazol-2-yl)buttersaeure-methylester (152563-97-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 70 percent / acetic acid / 5 h / Heating

2: 53 percent / NaCl / dimethylsulfoxide; H₂O / 18 h / 160 - 170 °C

3: 41 percent / 2,3-dichloro-5,6-dicyano-p-benzoquinone / tetrahydrofuran; H₂O / 1 h / 0 °C

4: 80 percent / NH₂OH*HCl, NaOAc*3H₂O / methanol; H₂O / 6 h / Heating

5: 90 percent / tetrahydrofuran / 1 h / 25 °C

6: 69 percent / hydrogen / 10 percent Pd/C / CH₂Cl₂ / 48 h / 760 Torr

With hydroxylamine hydrochloride; hydrogen; sodium acetate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; dimethyl sulfoxide;

upstream raw materials:

benzoic acid anhydride

2-(4-Acetoxyimino-1,2,3,4-tetrahydrocarbazol-2-yl)buttersaeure-methylester

dimethyl ethylmalonate

2-Ethyl-2-(3-oxocyclohexyl)malonsaeure-dimethylester