(1R,2R)-2-t-butyldiphenylsilyloxymethyl-1-[1-(4-chloro-2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

Base Information

Chemical Name:(1R,2R)-2-t-butyldiphenylsilyloxymethyl-1-[1-(4-chloro-2-vinylphenylamino)prop-2-en-1-yl]cyclopropane
CAS No.:1273298-72-8
Molecular Formula:C₃₁H₃₆ClNOSi
Molecular Weight:502.171
Hs Code.:

Synonyms:(1R,2R)-2-t-butyldiphenylsilyloxymethyl-1-[1-(4-chloro-2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

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Chemical Property of (1R,2R)-2-t-butyldiphenylsilyloxymethyl-1-[1-(4-chloro-2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

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Technology Process of (1R,2R)-2-t-butyldiphenylsilyloxymethyl-1-[1-(4-chloro-2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

There total 1 articles about (1R,2R)-2-t-butyldiphenylsilyloxymethyl-1-[1-(4-chloro-2-vinylphenylamino)prop-2-en-1-yl]cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1826-67-1
vinyl magnesium bromide

: 408348-31-2
(1R,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane

: 4-chloro-2-vinylaniline

: 1273298-72-8
(1R,2R)-2-t-butyldiphenylsilyloxymethyl-1-[1-(4-chloro-2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

Guidance literature:: (1R,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane; 4-chloro-2-vinylaniline; In diethyl ether; at 20 ℃; for 10h; Molecular sieve; Inert atmosphere;

With boron trifluoride diethyl etherate; In diethyl ether; at -40 ℃; for 0.5h; Inert atmosphere;

vinyl magnesium bromide; In diethyl ether; at -40 - 0 ℃; Inert atmosphere;
DOI:10.1039/c0ob00597e

Reference yield: 91.0%

: 1273298-72-8
(1R,2R)-2-t-butyldiphenylsilyloxymethyl-1-[1-(4-chloro-2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

: 108-24-7
acetic anhydride

: 1273298-28-4
C₃₃H₃₈ClNO₂Si

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In toluene; for 24h; Reflux; Inert atmosphere;
DOI:10.1039/c0ob00597e

Reference yield:

: 1273298-72-8
(1R,2R)-2-t-butyldiphenylsilyloxymethyl-1-[1-(4-chloro-2-vinylphenylamino)prop-2-en-1-yl]cyclopropane

: 1273298-31-9
(1R,2R)-2-t-butyldiphenylsilyloxymethyl-1-(5-chloro-N-acetylindole-2-yl)cyclopropane

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / toluene / 24 h / Reflux; Inert atmosphere

2: carbonylchlorohydridotris(triphenylphosphine)ruthenium (II) / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux; Inert atmosphere

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / 5,5-dimethyl-1,3-cyclohexadiene; toluene / 5 h / 120 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; carbonylchlorohydridotris(triphenylphosphine)ruthenium (II); N-ethyl-N,N-diisopropylamine; In 5,5-dimethyl-1,3-cyclohexadiene; toluene;
DOI:10.1039/c0ob00597e