7-hydroxy-8-[3-(4-hydroxy-3-methoxyphenyl)acryloyl]-4-methyl-2H-chromen-2-one

Base Information

Chemical Name:7-hydroxy-8-[3-(4-hydroxy-3-methoxyphenyl)acryloyl]-4-methyl-2H-chromen-2-one
CAS No.:148304-16-9
Molecular Formula:C₂₀H₁₆O₆
Molecular Weight:352.343
Hs Code.:
Mol file:148304-16-9.mol

Synonyms:7-hydroxy-8-((2E)-3-(3-methoxy-4-hydroxyphenyl)-1-oxo-2-propen-1-yl)-4-methyl-2H-1-benzopyran-2-one

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Chemical Property of 7-hydroxy-8-[3-(4-hydroxy-3-methoxyphenyl)acryloyl]-4-methyl-2H-chromen-2-one

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Technology Process of 7-hydroxy-8-[3-(4-hydroxy-3-methoxyphenyl)acryloyl]-4-methyl-2H-chromen-2-one

There total 8 articles about 7-hydroxy-8-[3-(4-hydroxy-3-methoxyphenyl)acryloyl]-4-methyl-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: C₂₇H₂₂O₆

: 148304-16-9
7-hydroxy-8-((2E)-3-(3-methoxy-4-hydroxyphenyl)-1-oxo-2-propen-1-yl)-4-methyl-2H-1-benzopyran-2-one

Guidance literature:: With titanium tetrachloride; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tet.2014.08.063

Reference yield: 80.0%

: 2555-29-5
8-acetyl-7-hydroxy-4-methyl-2H-chromen-2-one

: 121-33-5,8014-42-4
vanillin

: 148304-16-9
7-hydroxy-8-((2E)-3-(3-methoxy-4-hydroxyphenyl)-1-oxo-2-propen-1-yl)-4-methyl-2H-1-benzopyran-2-one

Guidance literature:: With piperidine; In ethanol; for 12h; Reflux;
DOI:10.1016/j.ejmech.2012.03.052

Reference yield:

: 108-46-3
recorcinol

: 148304-16-9
7-hydroxy-8-((2E)-3-(3-methoxy-4-hydroxyphenyl)-1-oxo-2-propen-1-yl)-4-methyl-2H-1-benzopyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 20 °C

2: dmap / tetrahydrofuran / 20 °C

3: aluminum (III) chloride / 2 h / 125 - 170 °C

4: piperidine / ethanol / Reflux

With piperidine; dmap; aluminum (III) chloride; sulfuric acid; In tetrahydrofuran; ethanol; 1: |Pechmann Condensation / 3: |Fries Phenol Ester Rearrangement / 4: |Claisen-Schmidt Condensation;
DOI:10.1139/cjc-2013-0053