1,1-dimethylethyl 4-{1-[(3,5-dichlorophenyl)-methyl]-2-oxo-3-pyrrolidinyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-{1-[(3,5-dichlorophenyl)-methyl]-2-oxo-3-pyrrolidinyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate
CAS No.:852880-50-3
Molecular Formula:C₂₇H₃₁Cl₂FN₂O₃
Molecular Weight:521.459
Hs Code.:

Synonyms:1,1-dimethylethyl 4-{1-[(3,5-dichlorophenyl)-methyl]-2-oxo-3-pyrrolidinyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-{1-[(3,5-dichlorophenyl)-methyl]-2-oxo-3-pyrrolidinyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate

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Technology Process of 1,1-dimethylethyl 4-{1-[(3,5-dichlorophenyl)-methyl]-2-oxo-3-pyrrolidinyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate

There total 1 articles about 1,1-dimethylethyl 4-{1-[(3,5-dichlorophenyl)-methyl]-2-oxo-3-pyrrolidinyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852880-49-0
1,1-dimethylethyl 4-(4-fluorophenyl)-4-{1-[(methyloxy)-carbonyl]-3-oxopropyl}-1-piperidinecarboxylate

: 39989-43-0
3,5-dichlorobenzylamine

: 852880-50-3
1,1-dimethylethyl 4-{1-[(3,5-dichlorophenyl)-methyl]-2-oxo-3-pyrrolidinyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate

Guidance literature:: 1,1-dimethylethyl 4-(4-fluorophenyl)-4-{1-[(methyloxy)-carbonyl]-3-oxopropyl}-1-piperidinecarboxylate; 3,5-dichlorobenzylamine; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

With water; sodium methylate; sodium hydrogencarbonate; more than 3 stages;

Reference yield:

: 852880-50-3
1,1-dimethylethyl 4-{1-[(3,5-dichlorophenyl)-methyl]-2-oxo-3-pyrrolidinyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate

: 852879-95-9
1-[(3,5-dichlorophenyl)-methyl]-3-[4-(4-fluorophenyl)-4-piperidinyl]-2-pyrrolidinone

Guidance literature:: 1,1-dimethylethyl 4-{1-[(3,5-dichlorophenyl)-methyl]-2-oxo-3-pyrrolidinyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In dichloromethane; water;